(Z)-(S)-8-(tert-Butyl-dimethyl-silanyloxy)-cyclodec-3-ene-1,1-dicarboxylic acid dibenzyl ester

Base Information

Chemical Name:(Z)-(S)-8-(tert-Butyl-dimethyl-silanyloxy)-cyclodec-3-ene-1,1-dicarboxylic acid dibenzyl ester
CAS No.:845252-88-2
Molecular Formula:C₃₂H₄₄O₅Si
Molecular Weight:536.784
Hs Code.:

Synonyms:(Z)-(S)-8-(tert-Butyl-dimethyl-silanyloxy)-cyclodec-3-ene-1,1-dicarboxylic acid dibenzyl ester

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Chemical Property of (Z)-(S)-8-(tert-Butyl-dimethyl-silanyloxy)-cyclodec-3-ene-1,1-dicarboxylic acid dibenzyl ester

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Technology Process of (Z)-(S)-8-(tert-Butyl-dimethyl-silanyloxy)-cyclodec-3-ene-1,1-dicarboxylic acid dibenzyl ester

There total 5 articles about (Z)-(S)-8-(tert-Butyl-dimethyl-silanyloxy)-cyclodec-3-ene-1,1-dicarboxylic acid dibenzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 753030-88-5
2-allyl-2-[3-(tert-butyl-dimethyl-silanyloxy)-oct-7-enyl]-malonic acid dibenzyl ester

: 845252-88-2
(Z)-(S)-8-(tert-Butyl-dimethyl-silanyloxy)-cyclodec-3-ene-1,1-dicarboxylic acid dibenzyl ester

Guidance literature:: 1,3-dimesityl-4,5-dihydroimidazol-2-ylidene-Ru catalyst; In dichloromethane; for 24h; Heating;
DOI:10.1021/ol049038x

Reference yield:

: 753030-85-2
3-hydroxy-oct-7-enethioic acid S-tert-butyl ester

: 845252-88-2
(Z)-(S)-8-(tert-Butyl-dimethyl-silanyloxy)-cyclodec-3-ene-1,1-dicarboxylic acid dibenzyl ester

Guidance literature:: Multi-step reaction with 5 steps

1.1: 100 percent / 2,6-lutidine / CH₂Cl₂ / 1 h

2.1: 93 percent / DIBALH / CH₂Cl₂; toluene / 2 h / -30 °C

3.1: 94 percent / PPh₃; imidazole; I₂ / CH₂Cl₂ / 2 h / 0 °C

4.1: NaH / tetrahydrofuran / 2 h / 0 °C

4.2: 94 percent / tetrahydrofuran / 13 h / 0 - 20 °C

5.1: 88 percent / 1,3-dimesityl-4,5-dihydroimidazol-2-ylidene-Ru catalyst / CH₂Cl₂ / 24 h / Heating

With 1H-imidazole; 2,6-dimethylpyridine; iodine; sodium hydride; diisobutylaluminium hydride; triphenylphosphine; 1,3-dimesityl-4,5-dihydroimidazol-2-ylidene-Ru catalyst; In tetrahydrofuran; dichloromethane; toluene;
DOI:10.1021/ol049038x

Reference yield:

: 753030-87-4
tert-butyl-[1-(2-iodo-ethyl)-hex-5-enyloxy]-dimethyl-silane

: 845252-88-2
(Z)-(S)-8-(tert-Butyl-dimethyl-silanyloxy)-cyclodec-3-ene-1,1-dicarboxylic acid dibenzyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: NaH / tetrahydrofuran / 2 h / 0 °C

1.2: 94 percent / tetrahydrofuran / 13 h / 0 - 20 °C

2.1: 88 percent / 1,3-dimesityl-4,5-dihydroimidazol-2-ylidene-Ru catalyst / CH₂Cl₂ / 24 h / Heating

With sodium hydride; 1,3-dimesityl-4,5-dihydroimidazol-2-ylidene-Ru catalyst; In tetrahydrofuran; dichloromethane;
DOI:10.1021/ol049038x