5'-O-(4,4'-dimethoxytrityl)-2'-deoxy-2'-(trifluoroacetamido)uridylyl (3'-5') 5'-amino-5'-deoxythymidine

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Chemical Name:5'-O-(4,4'-dimethoxytrityl)-2'-deoxy-2'-(trifluoroacetamido)uridylyl (3'-5') 5'-amino-5'-deoxythymidine
CAS No.:182005-99-8
Molecular Formula:C₄₂H₄₄F₃N₆O₁₄P
Molecular Weight:944.812
Hs Code.:

Synonyms:5'-O-(4,4'-dimethoxytrityl)-2'-deoxy-2'-(trifluoroacetamido)uridylyl (3'-5') 5'-amino-5'-deoxythymidine

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Chemical Property of 5'-O-(4,4'-dimethoxytrityl)-2'-deoxy-2'-(trifluoroacetamido)uridylyl (3'-5') 5'-amino-5'-deoxythymidine

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Technology Process of 5'-O-(4,4'-dimethoxytrityl)-2'-deoxy-2'-(trifluoroacetamido)uridylyl (3'-5') 5'-amino-5'-deoxythymidine

There total 4 articles about 5'-O-(4,4'-dimethoxytrityl)-2'-deoxy-2'-(trifluoroacetamido)uridylyl (3'-5') 5'-amino-5'-deoxythymidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: (R_p/S_p)-5'-O-(4,4'-dimethoxytrityl)-2'-deoxy-2'-(trifluoroacetamido)uridylyl (3'-5') 5'-amino-5'-deoxythymidine methyl ester

: 182005-99-8
5'-O-(4,4'-dimethoxytrityl)-2'-deoxy-2'-(trifluoroacetamido)uridylyl (3'-5') 5'-amino-5'-deoxythymidine

Guidance literature:: With thiophenol; triethylamine; In 1,4-dioxane; for 24h; Ambient temperature;
DOI:10.1021/jo960795l

Reference yield:

: 118849-17-5
5'-O-(4,4'-dimethoxytrityl)-2'-(trifluoroacetylamido)-2'-deoxyuridine

: 182005-99-8
5'-O-(4,4'-dimethoxytrityl)-2'-deoxy-2'-(trifluoroacetamido)uridylyl (3'-5') 5'-amino-5'-deoxythymidine

Guidance literature:: Multi-step reaction with 3 steps

1: tetrazole / acetonitrile; CH₂Cl₂ / 4 h / Ambient temperature

2: pyridine, LiCl / 20 h / Ambient temperature

3: 89 percent / Et₃N, thiophenol / dioxane / 24 h / Ambient temperature

With pyridine; 1H-tetrazole; thiophenol; triethylamine; lithium chloride; In 1,4-dioxane; dichloromethane; acetonitrile;
DOI:10.1021/jo960795l

Reference yield:

: Phosphorous acid (2R,3S,4R,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-4-(2,2,2-trifluoro-acetylamino)-tetrahydro-furan-3-yl ester dimethyl ester

: 182005-99-8
5'-O-(4,4'-dimethoxytrityl)-2'-deoxy-2'-(trifluoroacetamido)uridylyl (3'-5') 5'-amino-5'-deoxythymidine

Guidance literature:: Multi-step reaction with 2 steps

1: pyridine, LiCl / 20 h / Ambient temperature

2: 89 percent / Et₃N, thiophenol / dioxane / 24 h / Ambient temperature

With pyridine; thiophenol; triethylamine; lithium chloride; In 1,4-dioxane;
DOI:10.1021/jo960795l