2-Bromo-6-methyl-3-nitropyridine

Base Information

• Chemical Name: 2-Bromo-6-methyl-3-nitropyridine
• CAS No.: 374633-31-5
• Molecular Formula: C6H5BrN2O2
• Molecular Weight: 217.022
• Hs Code.: 2933399090
• Mol file: 374633-31-5.mol

Synonyms:2-Bromo-6-methyl-3-nitropyridine;2-Bromo-3-nitro-6-methylpyridine;

Chemical Property of 2-Bromo-6-methyl-3-nitropyridine

Chemical Property:

• Vapor Pressure: 0.0152mmHg at 25°C
• Refractive Index: 1.599
• Boiling Point: 265.2 °C at 760 mmHg
• Flash Point: 114.2 °C
• PSA: 58.71000
• Density: 1.709 g/cm³
• LogP: 2.58390
• Storage Temp.: 2-8°C

Purity/Quality:

99% ^*data from raw suppliers

2-Bromo-6-methyl-3-nitropyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: It is used as pharmaceutical intermediate.

Technology Process of 2-Bromo-6-methyl-3-nitropyridine

There total 1 articles about 2-Bromo-6-methyl-3-nitropyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

6-methyl-3-nitrohydropyridin-2-one (39745-39-6) → 2-bromo-6-methyl-3-nitropyridine (374633-31-5) + 2,5-dibromo-6-methyl-3-nitropyridine

Guidance literature:

With bromine; phosphorus tribromide;

DOI:10.1021/ja01627a078

Reference yield: 95.0%

2-bromo-6-methyl-3-nitropyridine (374633-31-5) + 4-methoxy-2-methylphenyl boronic acid (208399-66-0) → 2-(4-methoxy-2-methylphenyl)-6-methyl-3-nitropyridine

Guidance literature:

With potassium phosphate monohydrate; C₆₆H₈₄O₁₀P₂Pd; In water; ethyl acetate; toluene; at 45 ℃; for 10h; Reagent/catalyst; Solvent; Inert atmosphere;

DOI:10.1039/c8gc01356j

Reference yield: 90.0%

2-bromo-6-methyl-3-nitropyridine (374633-31-5) + 2-(((3-fluorophenyl)methoxy)phenyl)boronic acid (871126-24-8) → C19H15FN2O3

Guidance literature:

With C₃₅H₄₇O₃P*C₁₅H₁₆N^(1-)*CH₃O₃S^(1-)*Pd⁽²⁺⁾; triethylamine; In water; at 45 ℃; for 8h;

DOI:10.1039/c9sc02528f

upstream raw materials:

6-methyl-3-nitrohydropyridin-2-one

Downstream raw materials:

2-methyl-8,8-diphenyl-6,7,8,9-tetrahydro-dipyrido[1,2-a;3',2'-d]imidazole

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