4-(Bromomethyl)pyridine hydrobromide

Base Information

• Chemical Name: 4-(Bromomethyl)pyridine hydrobromide
• CAS No.: 73870-24-3
• Molecular Formula: C6H6BrN^.HBr
• Molecular Weight: 252.936
• Hs Code.: 29333990
• Mol file: 73870-24-3.mol

Synonyms:Pyridine,4-(bromomethyl)-, hydrobromide (6CI,9CI);(4-Pyridyl)methyl bromidehydrobromide;4-(Bromomethyl)pyridine hydrobromide;4-Picolyl bromidehydrobromide;

Chemical Property of 4-(Bromomethyl)pyridine hydrobromide

Chemical Property:

• Melting Point: 189-192 °C(lit.)
• PSA: 12.89000
• LogP: 2.93460
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• Water Solubility.: Soluble in water

Purity/Quality:

98%, ^*data from raw suppliers

4-(Bromomethyl)pyridine Hydrobromide ^*data from reagent suppliers

Safty Information:

• Pictogram(s): C
• Hazard Codes: C
• Statements: 34
• Safety Statements: 26-36/37/39-45

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 4-(Bromomethyl)pyridine hydrobromide may be used in the preparation of: 3-(4-pyridylmethyl)-2′,3′-di-O-oleyl-5′-O-(4,4′-dimethoxytriphenylmethyl)uridine3-(4-pyridylmethyl)-3′-O-oleyl-5′-O-(4,4-dimethoxytriphenylmethyl)-thymidine1,4-bis(N-hexyl-4-pyridinium)butadiene diperchlorateIt may also be used in the preparation of the following benzoxazine derivatives:2-morpholin-4-yl-7-(pyridin-4-ylmethoxy)-4H-1,3-benzoxazin-4-one8-methyl-2-morpholin-4-yl-7-(pyridin-4-ylmethoxy)-4H-1,3-benzoxazin-4-one2-morpholin-4-yl-8-(pyridin-4-ylmethoxy)-4H-1,3-benzoxazin-4-one

Technology Process of 4-(Bromomethyl)pyridine hydrobromide

There total 4 articles about 4-(Bromomethyl)pyridine hydrobromide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

4-(hydroxymethyl)pyridine hydrobromide (65737-59-9) → 4-bromomethyl pyridine hydrobromide (73870-24-3,1119106-77-2)

Guidance literature:

With phosphorus tribromide; In chloroform; at 45 ℃;

DOI:10.1016/j.ejmech.2020.112998

Reference yield: 58.1%

pyridine-4-methanol (586-95-8) → 4-bromomethyl pyridine hydrobromide (73870-24-3,1119106-77-2)

Guidance literature:

With phosphorus pentabromide; In chloroform;

Reference yield: 33.0%

→ 4-bromomethyl pyridine hydrobromide (73870-24-3,1119106-77-2)

Guidance literature:

upstream raw materials:

4-(hydroxymethyl)pyridine hydrobromide

pyridine-4-methanol

pyridine-4-carbaldehyde

Downstream raw materials:

NSC133593

N-(1-(pyridin-4-ylmethyl)piperidin-4-yl)-2-(4-(trifluoromethyl)benzyl)-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole-8-carboxamide

C₂₅H₁₈N₄O₂

tert-butyl (4-{3-phenyl-5-[(pyridin-4-ylmethoxy)methyl]-1,6-naphthyridin-2-yl}benzyl)carbamate

Refernces

• 1、 Engelhard, David M.,Nowack, Julia,Clever, Guido H.. "Copper-Induced Topology Switching and Thrombin Inhibition with Telomeric DNA G-Quadruplexes". supporting information. p. 11640 - 11644. Retrieved 2017/09/11.
• 2、 -. "NOVEL BENZODIOXANE AND BENZOXAZINE DERIVATIVES USEFUL AS CC CHEMOKINE RECEPTOR LIGANDS". Page/Page column 81. . Retrieved 2010/06/22.