Technology Process of [(2S,6S,9S)-10-(benzyloxy)-6-(methoxymethoxy)-9-methyldec-4-yn-2-yloxy](tert-butyl)dimethylsilane
There total 10 articles about [(2S,6S,9S)-10-(benzyloxy)-6-(methoxymethoxy)-9-methyldec-4-yn-2-yloxy](tert-butyl)dimethylsilane which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
tetra-(n-butyl)ammonium iodide; N-ethyl-N,N-diisopropylamine;
In
dichloromethane;
at 0 - 20 ℃;
Inert atmosphere;
DOI:10.1002/chem.201001752
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: potassium carbonate / methanol / 2 h / 20 °C / Inert atmosphere
2.1: zinc trifluoromethanesulfonate; triethylamine; N-methyl ephedrine / toluene / 20 °C / Inert atmosphere
2.2: 20 °C / Inert atmosphere
3.1: tetra-(n-butyl)ammonium iodide; N-ethyl-N,N-diisopropylamine / dichloromethane / 0 - 20 °C / Inert atmosphere
With
tetra-(n-butyl)ammonium iodide; zinc trifluoromethanesulfonate; potassium carbonate; triethylamine; N-ethyl-N,N-diisopropylamine; N-methyl ephedrine;
In
methanol; dichloromethane; toluene;
DOI:10.1002/chem.201001752
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / -90 °C / Inert atmosphere
1.2: -90 - 20 °C / Inert atmosphere
2.1: zinc trifluoromethanesulfonate; triethylamine; N-methyl ephedrine / toluene / 20 °C / Inert atmosphere
2.2: 20 °C / Inert atmosphere
3.1: tetra-(n-butyl)ammonium iodide; N-ethyl-N,N-diisopropylamine / dichloromethane / 0 - 20 °C / Inert atmosphere
With
oxalyl dichloride; tetra-(n-butyl)ammonium iodide; zinc trifluoromethanesulfonate; dimethyl sulfoxide; triethylamine; N-ethyl-N,N-diisopropylamine; N-methyl ephedrine;
In
dichloromethane; toluene;
1.1: Swern oxidation / 1.2: Swern oxidation;
DOI:10.1002/chem.201001752
