(S)-methyl 3-methyl-2-((S)-2-(4-methylphenylsulfonamido)propylamino)butanoate

Base Information

Chemical Name:(S)-methyl 3-methyl-2-((S)-2-(4-methylphenylsulfonamido)propylamino)butanoate
CAS No.:1264148-69-7
Molecular Formula:C₁₆H₂₆N₂O₄S
Molecular Weight:342.459
Hs Code.:

Synonyms:(S)-methyl 3-methyl-2-((S)-2-(4-methylphenylsulfonamido)propylamino)butanoate

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Chemical Property of (S)-methyl 3-methyl-2-((S)-2-(4-methylphenylsulfonamido)propylamino)butanoate

Chemical Property:

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Technology Process of (S)-methyl 3-methyl-2-((S)-2-(4-methylphenylsulfonamido)propylamino)butanoate

There total 3 articles about (S)-methyl 3-methyl-2-((S)-2-(4-methylphenylsulfonamido)propylamino)butanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 28.0%

: 6306-52-1
L-valine methylester hydrochloride

: 119461-40-4
S-(+)-2-methyl-N-p-tosylaziridine

: 1264148-69-7
(S)-methyl 3-methyl-2-((S)-2-(4-methylphenylsulfonamido)propylamino)butanoate

Guidance literature:: L-valine methylester hydrochloride; S-(+)-2-methyl-N-p-tosylaziridine; With triethylamine; In tetrahydrofuran; at 0 ℃; for 0.0833333h;

With boron trifluoride diethyl etherate; In tetrahydrofuran; at 0 - 60 ℃; regioselective reaction;
DOI:10.1002/asia.201000554

Reference yield:

: 59724-69-5
(S)-N-tosylalanine methyl ester

: 1264148-69-7
(S)-methyl 3-methyl-2-((S)-2-(4-methylphenylsulfonamido)propylamino)butanoate

Guidance literature:: Multi-step reaction with 3 steps

1.1: lithium borohydride / tetrahydrofuran / 0 - 20 °C

2.1: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran / 2 h / 0 °C / Inert atmosphere

3.1: triethylamine / tetrahydrofuran / 0.08 h / 0 °C

3.2: 0 - 60 °C

With lithium borohydride; triethylamine; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; 2.1: Mitsunobu cyclization;
DOI:10.1002/asia.201000554

Reference yield:

: 100132-60-3,114663-10-4,139758-16-0
(S)-2-(toluene-4-sulfonamido)propan-1-ol

: 1264148-69-7
(S)-methyl 3-methyl-2-((S)-2-(4-methylphenylsulfonamido)propylamino)butanoate

Guidance literature:: Multi-step reaction with 2 steps

1.1: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran / 2 h / 0 °C / Inert atmosphere

2.1: triethylamine / tetrahydrofuran / 0.08 h / 0 °C

2.2: 0 - 60 °C

With triethylamine; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; 1.1: Mitsunobu cyclization;
DOI:10.1002/asia.201000554