methyl {(2R)-3-oxo-1,2,3,4-tetrahydroquinoxalin-2-yl}acetate

Base Information

• Chemical Name: methyl {(2R)-3-oxo-1,2,3,4-tetrahydroquinoxalin-2-yl}acetate
• CAS No.: 565460-55-1
• Molecular Formula: C₁₁H₁₂N₂O₃
• Molecular Weight: 220.228
• Mol file: 565460-55-1.mol

Synonyms:methyl {(2R)-3-oxo-1,2,3,4-tetrahydroquinoxalin-2-yl}acetate

Chemical Property of methyl {(2R)-3-oxo-1,2,3,4-tetrahydroquinoxalin-2-yl}acetate

Chemical Property:

Purity/Quality:

97% ^*data from raw suppliers

(R)-Methyl2-(3-oxo-1,2,3,4-tetrahydroquinoxalin-2-yl)acetate 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl {(2R)-3-oxo-1,2,3,4-tetrahydroquinoxalin-2-yl}acetate

There total 4 articles about methyl {(2R)-3-oxo-1,2,3,4-tetrahydroquinoxalin-2-yl}acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

dimethyl (2R)-2-(2-nitrophenylamino)butanedioate (565460-54-0) → methyl {(2R)-3-oxo-1,2,3,4-tetrahydroquinoxalin-2-yl}acetate (565460-55-1)

Guidance literature:

With hydrogen; platinum(IV) oxide; In methanol; for 6h; under 2482.38 Torr;

Reference yield: 98.0%

dimethyl (2-nitrophenyl)-L-aspartate (714568-86-2) → methyl {(2R)-3-oxo-1,2,3,4-tetrahydroquinoxalin-2-yl}acetate (565460-55-1)

Guidance literature:

With hydrogen; palladium 10% on activated carbon; In ethanol; for 48h;

Reference yield:

dimethyl D-aspartate (6384-18-5,40149-67-5,88067-96-3) → methyl {(2R)-3-oxo-1,2,3,4-tetrahydroquinoxalin-2-yl}acetate (565460-55-1)

Guidance literature:

Multi-step reaction with 2 steps

1.1: NaHCO₃ / methanol / Heating

1.2: 81 percent / HCl / methanol

2.1: 98 percent / H₂ / Pd/C / ethanol

With hydrogen; sodium hydrogencarbonate; palladium on activated charcoal; In methanol; ethanol;

DOI:10.1016/j.bmcl.2004.09.074

upstream raw materials:

dimethyl (2R)-2-(2-nitrophenylamino)butanedioate

dimethyl D-aspartate

ortho-nitrofluorobenzene

dimethyl (2-nitrophenyl)-L-aspartate

Downstream raw materials:

C₁₈H₁₈N₂O₅S

(3R)-3-(2-aminoethyl)-4-[(3,4-dichloro-phenyl)sulfonyl]-3,4-dihydroquinoxalin-2(1H)-one

C₁₇H₁₆N₂O₅S

N-[2-(4-cyanophenyl)ethyl]-2-{(2R)-1-[(3,4-dichlorophenyl)sulfonyl]-3-oxo-1,2,3,4-tetrahydroquinoxalin-2-yl}acetamide