(2S)-N-[4-hydroxy-5-methoxy-2-nitrobenzoyl]-4,4-difluoropyrrolidine-2-carboxaldehyde diethyl-dithioacetal

Base Information

• Chemical Name: (2S)-N-[4-hydroxy-5-methoxy-2-nitrobenzoyl]-4,4-difluoropyrrolidine-2-carboxaldehyde diethyl-dithioacetal
• CAS No.: 950191-35-2
• Molecular Formula: C₁₇H₂₂F₂N₂O₅S₂
• Molecular Weight: 436.501

Synonyms:(2S)-N-[4-hydroxy-5-methoxy-2-nitrobenzoyl]-4,4-difluoropyrrolidine-2-carboxaldehyde diethyl-dithioacetal

Chemical Property of (2S)-N-[4-hydroxy-5-methoxy-2-nitrobenzoyl]-4,4-difluoropyrrolidine-2-carboxaldehyde diethyl-dithioacetal

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2S)-N-[4-hydroxy-5-methoxy-2-nitrobenzoyl]-4,4-difluoropyrrolidine-2-carboxaldehyde diethyl-dithioacetal

There total 1 articles about (2S)-N-[4-hydroxy-5-methoxy-2-nitrobenzoyl]-4,4-difluoropyrrolidine-2-carboxaldehyde diethyl-dithioacetal which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

(2S)-N-(4-benzyloxy-5-methoxy-2-nitrobenzoyl)-4,4-difluoropyrrolidine-2-carboxaldehyde di(ethylthio)acetal (1145663-59-7) → (2S)-N-[4-hydroxy-5-methoxy-2-nitrobenzoyl]-4,4-difluoropyrrolidine-2-carboxaldehyde diethyl-dithioacetal (950191-35-2)

Guidance literature:

With boron trifluoride diethyl etherate; ethanethiol; In dichloromethane; at 20 ℃;

DOI:10.1016/j.bmc.2008.12.068

Reference yield: 88.0%

(2S)-N-[4-hydroxy-5-methoxy-2-nitrobenzoyl]-4,4-difluoropyrrolidine-2-carboxaldehyde diethyl-dithioacetal (950191-35-2) → (2S)-N-(4-hydroxy-5-methoxy-2-aminobenzoyl)-4,4-difluoropyrrolidine-2-carboxaldehyde di(ethylthio)acetal (1145663-13-3)

Guidance literature:

With methanol; tin(II) chloride dihdyrate; Reflux;

DOI:10.1016/j.bmc.2008.12.068

Reference yield: 86.0%

(2S)-N-[4-hydroxy-5-methoxy-2-nitrobenzoyl]-4,4-difluoropyrrolidine-2-carboxaldehyde diethyl-dithioacetal (950191-35-2) + 3-(5-bromopentoxy)-estra-1,3,5(10)-triene-17β-ol (22034-75-9) → (2S)-N-[4-{5-(17-hydroxy-1,3,5(10)-estratrien-3-yloxy)-pentyloxy}-5-methoxy-2-nitrobenzoyl]-4,4-difluoropyrrolidine-2-carboxaldehyde diethyl-dithioacetal (1307900-87-3)

Guidance literature:

With potassium carbonate; In acetone; at 60 ℃; for 10h;

DOI:10.1016/j.bmc.2011.03.015

upstream raw materials:

(2S)-N-(4-benzyloxy-5-methoxy-2-nitrobenzoyl)-4,4-difluoropyrrolidine-2-carboxaldehyde di(ethylthio)acetal

Downstream raw materials:

(2S)-N-[4-(4-bromobutanoxy)-5-methoxy-2-nitrobenzoyl]-4,4-difluoropyrrolidine-2-carboxaldehyde di(ethylthio)acetal

(2S)-N-(4-hydroxy-5-methoxy-2-aminobenzoyl)-4,4-difluoropyrrolidine-2-carboxaldehyde di(ethylthio)acetal

(2S)-N-[4-(5-bromopentanoxy)-5-methoxy-2-nitrobenzoyl]-4,4-difluoropyrrolidine-2-carboxaldehyde di(ethylthio)acetal

(2S)-N-[4-(3-bromopropoxy)-5-methoxy-2-nitrobenzoyl]-4,4-difluoropyrrolidine-2-carboxaldehyde di(ethylthio)acetal

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 950191-35-2 (2S)-N-[4-hydroxy-5-methoxy-2-nitrobenzoyl]-4,4-difluoropyrrolidine-2-carboxaldehyde diethyl-dithioacetal

Send

Send

Metric Ton KG G Pound L ML

Send

Send