4-(4-bromophenyl)-1-[(1-methylpyrrol-2-yl)acetyl]semicarbazide

Base Information

• Chemical Name: 4-(4-bromophenyl)-1-[(1-methylpyrrol-2-yl)acetyl]semicarbazide
• CAS No.: 891005-41-7
• Molecular Formula: C₁₄H₁₅BrN₄O₂
• Molecular Weight: 351.203
• Mol file: 891005-41-7.mol

Synonyms:4-(4-bromophenyl)-1-[(1-methylpyrrol-2-yl)acetyl]semicarbazide

Chemical Property of 4-(4-bromophenyl)-1-[(1-methylpyrrol-2-yl)acetyl]semicarbazide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

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Technology Process of 4-(4-bromophenyl)-1-[(1-methylpyrrol-2-yl)acetyl]semicarbazide

There total 2 articles about 4-(4-bromophenyl)-1-[(1-methylpyrrol-2-yl)acetyl]semicarbazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

(1-methyl-pyrrol-2-yl)acetic acid hydrazide (158144-17-3) + 4-bromophenyl isocyanate (2493-02-9) → 4-(4-bromophenyl)-1-[(1-methylpyrrol-2-yl)acetyl]semicarbazide (891005-41-7)

Guidance literature:

In N,N-dimethyl acetamide; at 20 ℃; for 24h;

DOI:10.1515/znb-2009-0514

Reference yield:

ethyl (1-methyl-1H-pyrrol-2-yl)acetate (49669-45-6) → 4-(4-bromophenyl)-1-[(1-methylpyrrol-2-yl)acetyl]semicarbazide (891005-41-7)

Guidance literature:

Multi-step reaction with 2 steps

1: hydrazine hydrate / ethanol

2: diethyl ether; N,N-dimethyl acetamide

With hydrazine hydrate; In diethyl ether; ethanol; N,N-dimethyl acetamide;

DOI:10.1515/znb-2011-0511

Reference yield: 89.0%

4-(4-bromophenyl)-1-[(1-methylpyrrol-2-yl)acetyl]semicarbazide (891005-41-7) → 4-bromophenyl-3-[(1-methylpyrrol-2-yl)methyl]-4,5-dihydro-1,2,4-triazolin-5-one (1217115-30-4)

Guidance literature:

With sodium hydroxide; In water; Reflux;

DOI:10.1515/znb-2009-0514

upstream raw materials:

(1-methyl-pyrrol-2-yl)acetic acid hydrazide

4-bromophenyl isocyanate

ethyl (1-methyl-1H-pyrrol-2-yl)acetate

Downstream raw materials:

4-bromophenyl-3-[(1-methylpyrrol-2-yl)methyl]-4,5-dihydro-1,2,4-triazolin-5-one