4-Butyl-2-methylaniline

Base Information

• Chemical Name: 4-Butyl-2-methylaniline
• CAS No.: 72072-16-3
• Molecular Formula: C11H17N
• Molecular Weight: 163.263
• Hs Code.: 2921430090
• Mol file: 72072-16-3.mol

Synonyms:2-Methyl-4-butylaniline;4-Butyl-2-methylaniline;

Chemical Property of 4-Butyl-2-methylaniline

Chemical Property:

• Vapor Pressure: 0.0098mmHg at 25°C
• Refractive Index: 1.535
• Boiling Point: 264.3 °C at 760 mmHg
• PKA: 4.75±0.10(Predicted)
• Flash Point: 115.7 °C
• PSA: 26.02000
• Density: 0.939 g/cm³
• LogP: 3.50100
• Storage Temp.: Refrigerator
• Solubility.: Chloroform (Slightly), Ethyl Acetate (Slightly)

Purity/Quality:

99% ^*data from raw suppliers

4-Butyl-2-methylaniline ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 20/21/22-53
• Safety Statements: 36/37

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 4-Butyl-2-methylaniline is used for the preparation of a number of substituted acetamides which are antagonists of MDR proteins for treatment of drug-resistant cancers.

Technology Process of 4-Butyl-2-methylaniline

There total 3 articles about 4-Butyl-2-methylaniline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.1%

benzyl N-(4-butyl-2-methyl-phenyl)carbamate → 4-butyl-2-methyl-aniline (72072-16-3)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In methanol; at 15 ℃; for 2h; under 775.743 Torr;

Reference yield:

4-butyl-2-methylbenzoic acid → 4-butyl-2-methyl-aniline (72072-16-3)

Guidance literature:

Multi-step reaction with 2 steps

1: triethylamine; diphenyl phosphoryl azide / toluene / 12 h / 100 °C

2: palladium 10% on activated carbon; hydrogen / methanol / 2 h / 15 °C / 775.74 Torr

With diphenyl phosphoryl azide; palladium 10% on activated carbon; hydrogen; triethylamine; In methanol; toluene;

Reference yield:

o-toluidine (95-53-4) + butan-1-ol (71-36-3) → 4-butyl-2-methyl-aniline (72072-16-3)

Guidance literature:

at 180 - 200 ℃;

upstream raw materials:

o-toluidine

butan-1-ol

Downstream raw materials:

N-(4-butyl-2-methyl-phenyl)-acetamide

4-(4-butyl-2-methylphenyl)-3-(2,6-dimethylphenyl)-5-phenyl-4H-1,2,4-triazole

(4-butyl-2-methylphenyl)(2-methylpropyl)amine

3-[(4-{[(4-butyl-2-methylphenyl)(2-methylpropyl)amino]sulfonyl}-2-methylphenyl)oxy]propanoic acid