2-(2-{N-[(1-hydroxycyclohexyl)methyl]glycyl}-1,2,3,4-tetrahydroisoquinolin-1-yl)propan-2-yl pivalate

Base Information

Chemical Name:2-(2-{N-[(1-hydroxycyclohexyl)methyl]glycyl}-1,2,3,4-tetrahydroisoquinolin-1-yl)propan-2-yl pivalate
CAS No.:1085539-79-2
Molecular Formula:C₂₆H₄₀N₂O₄
Molecular Weight:444.615
Hs Code.:

Synonyms:2-(2-{N-[(1-hydroxycyclohexyl)methyl]glycyl}-1,2,3,4-tetrahydroisoquinolin-1-yl)propan-2-yl pivalate

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Chemical Property of 2-(2-{N-[(1-hydroxycyclohexyl)methyl]glycyl}-1,2,3,4-tetrahydroisoquinolin-1-yl)propan-2-yl pivalate

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Technology Process of 2-(2-{N-[(1-hydroxycyclohexyl)methyl]glycyl}-1,2,3,4-tetrahydroisoquinolin-1-yl)propan-2-yl pivalate

There total 3 articles about 2-(2-{N-[(1-hydroxycyclohexyl)methyl]glycyl}-1,2,3,4-tetrahydroisoquinolin-1-yl)propan-2-yl pivalate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1085538-90-4
1-[2-(chloroacetyl)-1,2,3,4-tetrahydroisoquinolin-1-yl]-1-methylethyl pivalate

: 19968-85-5
1-(aminomethyl)cyclohexanol hydrochloride

: 1085539-79-2
2-(2-{N-[(1-hydroxycyclohexyl)methyl]glycyl}-1,2,3,4-tetrahydroisoquinolin-1-yl)propan-2-yl pivalate

Guidance literature:: With tetra-(n-butyl)ammonium iodide; potassium carbonate; In acetonitrile; at 60 ℃; for 5h;

Reference yield:

: 76068-81-0
1-(3,4-dihydroisoquinolin-2(1H)-yl)-2,2-dimethylpropan-1-one

: 1085539-79-2
2-(2-{N-[(1-hydroxycyclohexyl)methyl]glycyl}-1,2,3,4-tetrahydroisoquinolin-1-yl)propan-2-yl pivalate

Guidance literature:: Multi-step reaction with 4 steps

1.1: 2,3-dimethyl-2,3-diaminobutane; tert.-butyl lithium / tetrahydrofuran; pentane / 0.17 h / -78 °C

1.2: 1 h / -78 °C

2.1: trifluoroacetic acid / 4 h / 20 °C

3.1: 20 °C / Alkaline conditions

4.1: potassium carbonate

With 2,3-dimethyl-2,3-diaminobutane; tert.-butyl lithium; potassium carbonate; trifluoroacetic acid; In tetrahydrofuran; pentane;
DOI:10.1016/j.bmc.2015.05.030

Reference yield:

: 1085538-88-0
1-[1-(2-hydroxypropan-2-yl)-3,4-dihydroisoquinolin-2(1H)-yl]-2,2-dimethylpropan-1-one

: 1085539-79-2
2-(2-{N-[(1-hydroxycyclohexyl)methyl]glycyl}-1,2,3,4-tetrahydroisoquinolin-1-yl)propan-2-yl pivalate

Guidance literature:: Multi-step reaction with 3 steps

1: trifluoroacetic acid / 4 h / 20 °C

2: 20 °C / Alkaline conditions

3: potassium carbonate

With potassium carbonate; trifluoroacetic acid;
DOI:10.1016/j.bmc.2015.05.030