Technology Process of 2-[4-methoxy-3-(pyridin-2-ylethynyl)benzoyl]isoindoline
There total 4 articles about 2-[4-methoxy-3-(pyridin-2-ylethynyl)benzoyl]isoindoline which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
4-methoxy-3-(pyridin-2-ylethynyl)benzoic acid;
With
benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride;
In
dichloromethane;
for 0.25h;
isoindoline;
With
triethylamine;
In
dichloromethane;
for 5h;
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: copper(l) iodide; triethylamine / bis-triphenylphosphine-palladium(II) chloride / toluene / 6 h / 100 °C / Inert atmosphere
2.1: lithium hydroxide monohydrate / tetrahydrofuran; methanol; water / 20 °C
2.2: pH 4 / Acidic aqueous solution
3.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 0.25 h
3.2: 5 h
With
copper(l) iodide; lithium hydroxide monohydrate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine;
bis-triphenylphosphine-palladium(II) chloride;
In
tetrahydrofuran; methanol; dichloromethane; water; toluene;
1.1: Sonogashira Coupling;
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: copper(l) iodide; triethylamine / bis-triphenylphosphine-palladium(II) chloride / toluene / 6 h / 100 °C / Inert atmosphere
2.1: lithium hydroxide monohydrate / tetrahydrofuran; methanol; water / 20 °C
2.2: pH 4 / Acidic aqueous solution
3.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 0.25 h
3.2: 5 h
With
copper(l) iodide; lithium hydroxide monohydrate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine;
bis-triphenylphosphine-palladium(II) chloride;
In
tetrahydrofuran; methanol; dichloromethane; water; toluene;
1.1: Sonogashira Coupling;
