(6R,8S)-1-Benzyl-8-(tert-butyl-dimethyl-silanyloxy)-1-aza-spiro[5.5]undecane

Base Information

Chemical Name:(6R,8S)-1-Benzyl-8-(tert-butyl-dimethyl-silanyloxy)-1-aza-spiro[5.5]undecane
CAS No.:99499-67-9
Molecular Formula:C₂₃H₃₉NOSi
Molecular Weight:373.654
Hs Code.:

Synonyms:(6R,8S)-1-Benzyl-8-(tert-butyl-dimethyl-silanyloxy)-1-aza-spiro[5.5]undecane

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (6R,8S)-1-Benzyl-8-(tert-butyl-dimethyl-silanyloxy)-1-aza-spiro[5.5]undecane

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Technology Process of (6R,8S)-1-Benzyl-8-(tert-butyl-dimethyl-silanyloxy)-1-aza-spiro[5.5]undecane

There total 14 articles about (6R,8S)-1-Benzyl-8-(tert-butyl-dimethyl-silanyloxy)-1-aza-spiro[5.5]undecane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 99499-64-6,109717-62-6
(6S,7R,8R)-1-Benzyl-8-(tert-butyl-dimethyl-silanyloxy)-7-iodo-1-aza-spiro[5.5]undecane

: 99499-67-9
(6R,8S)-1-Benzyl-8-(tert-butyl-dimethyl-silanyloxy)-1-aza-spiro[5.5]undecane

Guidance literature:: With tri-n-butyl-tin hydride; In benzene;
DOI:10.1016/S0040-4039(00)89277-1

Reference yield: 76.0%

: 99499-66-8,109717-64-8
Methanesulfonic acid (6S,8R)-1-benzyl-8-(tert-butyl-dimethyl-silanyloxy)-1-aza-spiro[5.5]undec-7-yl ester

: 99499-67-9
(6R,8S)-1-Benzyl-8-(tert-butyl-dimethyl-silanyloxy)-1-aza-spiro[5.5]undecane

Guidance literature:: With lithium aluminium tetrahydride; In tetrahydrofuran;
DOI:10.1016/S0040-4039(00)89277-1

Reference yield:

: 5323-87-5
3-Ethoxycyclohex-2-en-1-one

: 99499-67-9
(6R,8S)-1-Benzyl-8-(tert-butyl-dimethyl-silanyloxy)-1-aza-spiro[5.5]undecane

Guidance literature:: Multi-step reaction with 8 steps

1: 85 percent / tetrahydrofuran

2: 97 percent / DIBAL / CH₂Cl₂

3: 98 percent / imidazole / dimethylformamide

4: 100 percent / H₂ / Pd(OH)2/C / ethanol

5: 93 percent / pyridine

6: 85 percent / NaI / dimethylsulfoxide

7: 90 percent / I₂ / CH₂Cl₂

8: 80 percent / (Bu)3SnH / benzene

With 1H-imidazole; hydrogen; iodine; tri-n-butyl-tin hydride; diisobutylaluminium hydride; palladium dihydroxide; sodium iodide; In tetrahydrofuran; pyridine; ethanol; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide; benzene;
DOI:10.1016/S0040-4039(00)89277-1