1-(3-{5-[3-(6-amino-5-trifluoromethyl-pyridin-3-yl)-2-methyl-imidazo[1,2-b]pyridazin-6-yl]-2-methoxy-phenoxy}-propyl)-3-(3-methoxy-phenyl)-urea

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Chemical Name:1-(3-{5-[3-(6-amino-5-trifluoromethyl-pyridin-3-yl)-2-methyl-imidazo[1,2-b]pyridazin-6-yl]-2-methoxy-phenoxy}-propyl)-3-(3-methoxy-phenyl)-urea
CAS No.:1083429-55-3
Molecular Formula:C₃₁H₃₀F₃N₇O₄
Molecular Weight:621.619
Hs Code.:

Synonyms:1-(3-{5-[3-(6-amino-5-trifluoromethyl-pyridin-3-yl)-2-methyl-imidazo[1,2-b]pyridazin-6-yl]-2-methoxy-phenoxy}-propyl)-3-(3-methoxy-phenyl)-urea

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Chemical Property of 1-(3-{5-[3-(6-amino-5-trifluoromethyl-pyridin-3-yl)-2-methyl-imidazo[1,2-b]pyridazin-6-yl]-2-methoxy-phenoxy}-propyl)-3-(3-methoxy-phenyl)-urea

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Technology Process of 1-(3-{5-[3-(6-amino-5-trifluoromethyl-pyridin-3-yl)-2-methyl-imidazo[1,2-b]pyridazin-6-yl]-2-methoxy-phenoxy}-propyl)-3-(3-methoxy-phenyl)-urea

There total 9 articles about 1-(3-{5-[3-(6-amino-5-trifluoromethyl-pyridin-3-yl)-2-methyl-imidazo[1,2-b]pyridazin-6-yl]-2-methoxy-phenoxy}-propyl)-3-(3-methoxy-phenyl)-urea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 1083430-95-8
5-{6-[3-(3-amino-propoxy)-4-methoxy-phenyl]-2-methyl-imidazo[1,2-b]pyridazin-3-yl}-3-trifluoromethyl-pyridin-2-ylamine

: 18908-07-1
3-methoxyphenyl isocyanate

: 1083429-55-3
1-(3-{5-[3-(6-amino-5-trifluoromethyl-pyridin-3-yl)-2-methyl-imidazo[1,2-b]pyridazin-6-yl]-2-methoxy-phenoxy}-propyl)-3-(3-methoxy-phenyl)-urea

Guidance literature:: 5-{6-[3-(3-amino-propoxy)-4-methoxy-phenyl]-2-methyl-imidazo[1,2-b]pyridazin-3-yl}-3-trifluoromethyl-pyridin-2-ylamine; 3-methoxyphenyl isocyanate; With triethylamine; In N,N-dimethyl-formamide; at 0 ℃; for 0.166667h;

With sodium hydrogencarbonate; In water; N,N-dimethyl-formamide; at 0 ℃; for 0.166667h;

Reference yield:

: 79456-34-1
5-bromo-3-(trifluoromethyl)pyridin-2-amine

: 1083429-55-3
1-(3-{5-[3-(6-amino-5-trifluoromethyl-pyridin-3-yl)-2-methyl-imidazo[1,2-b]pyridazin-6-yl]-2-methoxy-phenoxy}-propyl)-3-(3-methoxy-phenyl)-urea

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium acetate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane / 8 h / 115 °C

2.1: potassium carbonate / bis-triphenylphosphine-palladium(II) chloride / ISOPROPYLAMIDE; water / 0.75 h / 150 °C / Microwave irradiation

3.1: potassium carbonate / ISOPROPYLAMIDE / 0.75 h / 100 °C / Microwave irradiation

4.1: trifluoroacetic acid / dichloromethane / 0 °C

5.1: triethylamine / N,N-dimethyl-formamide / 0.17 h / 0 °C

5.2: 0.17 h / 0 °C

With potassium acetate; potassium carbonate; triethylamine; trifluoroacetic acid; bis-triphenylphosphine-palladium(II) chloride; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In 1,4-dioxane; dichloromethane; ISOPROPYLAMIDE; water; N,N-dimethyl-formamide;

Reference yield:

: 14793-00-1
6-chloro-2-methylimidazo-<1,2-b>pyridazine

: 1083429-55-3
1-(3-{5-[3-(6-amino-5-trifluoromethyl-pyridin-3-yl)-2-methyl-imidazo[1,2-b]pyridazin-6-yl]-2-methoxy-phenoxy}-propyl)-3-(3-methoxy-phenyl)-urea

Guidance literature:: Multi-step reaction with 6 steps

1.1: potassium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / ethanol; toluene / 1 h / 110 °C / Microwave irradiation

2.1: N-Bromosuccinimide / N,N-dimethyl-formamide / 1 h / 0 °C

3.1: potassium carbonate / bis-triphenylphosphine-palladium(II) chloride / ISOPROPYLAMIDE; water / 0.75 h / 150 °C / Microwave irradiation

4.1: potassium carbonate / ISOPROPYLAMIDE / 0.75 h / 100 °C / Microwave irradiation

5.1: trifluoroacetic acid / dichloromethane / 0 °C

6.1: triethylamine / N,N-dimethyl-formamide / 0.17 h / 0 °C

6.2: 0.17 h / 0 °C

With N-Bromosuccinimide; potassium carbonate; triethylamine; trifluoroacetic acid; bis-triphenylphosphine-palladium(II) chloride; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In ethanol; dichloromethane; ISOPROPYLAMIDE; water; N,N-dimethyl-formamide; toluene;