6-methoxy-8-(phenylsulfonyl)-1,3,4,8-tetrahydro-2H-[1,4]oxazepino[6,7-e]indole

Base Information

Chemical Name:6-methoxy-8-(phenylsulfonyl)-1,3,4,8-tetrahydro-2H-[1,4]oxazepino[6,7-e]indole
CAS No.:1022954-83-1
Molecular Formula:C₁₈H₁₈N₂O₄S
Molecular Weight:358.418
Hs Code.:

Synonyms:6-methoxy-8-(phenylsulfonyl)-1,3,4,8-tetrahydro-2H-[1,4]oxazepino[6,7-e]indole

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Chemical Property of 6-methoxy-8-(phenylsulfonyl)-1,3,4,8-tetrahydro-2H-[1,4]oxazepino[6,7-e]indole

Chemical Property:

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Technology Process of 6-methoxy-8-(phenylsulfonyl)-1,3,4,8-tetrahydro-2H-[1,4]oxazepino[6,7-e]indole

There total 5 articles about 6-methoxy-8-(phenylsulfonyl)-1,3,4,8-tetrahydro-2H-[1,4]oxazepino[6,7-e]indole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1022953-74-7
6-methoxy-2-methyl-8-(phenylsulfonyl)-1,3,4,8-tetrahydro-2H-[1,4]oxazepino[6,7-e]indole

: 1022954-83-1
6-methoxy-8-(phenylsulfonyl)-1,3,4,8-tetrahydro-2H-[1,4]oxazepino[6,7-e]indole

Guidance literature:: 6-methoxy-2-methyl-8-(phenylsulfonyl)-1,3,4,8-tetrahydro-2H-[1,4]oxazepino[6,7-e]indole; With carbonochloridic acid 1-chloro-ethyl ester; N,N,N',N'-tetramethyl-1,8-diaminonaphthalene; In dichloromethane; at 20 ℃; for 0.5h;

In methanol; for 2h; Heating / reflux;

Reference yield:

: 5-(benzyloxy)-6-methoxy-1-(phenylsulfonyl)-1H-indole

: 1022954-83-1
6-methoxy-8-(phenylsulfonyl)-1,3,4,8-tetrahydro-2H-[1,4]oxazepino[6,7-e]indole

Guidance literature:: Multi-step reaction with 4 steps

1.1: hydrogenchloride; cyclohexene / palladium 10% on activated carbon / ethanol; water / 0.08 h / 150 °C / Microwave irradiation

2.1: ethanol / 0.08 h / 65 °C

2.2: 2 h / 70 °C

3.1: diamide; triphenylphosphine / tetrahydrofuran / 1.5 h / 150 °C / Microwave irradiation

4.1: carbonochloridic acid 1-chloro-ethyl ester; N,N,N',N'-tetramethyl-1,8-diaminonaphthalene / dichloromethane / 0.5 h / 20 °C

4.2: 2 h / Heating / reflux

With hydrogenchloride; carbonochloridic acid 1-chloro-ethyl ester; diamide; N,N,N',N'-tetramethyl-1,8-diaminonaphthalene; triphenylphosphine; cyclohexene; palladium 10% on activated carbon; In tetrahydrofuran; ethanol; dichloromethane; water;

Reference yield:

: 4790-04-9
5-benzyloxy-6-methoxy-indole

: 1022954-83-1
6-methoxy-8-(phenylsulfonyl)-1,3,4,8-tetrahydro-2H-[1,4]oxazepino[6,7-e]indole

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium hydroxide; tetra(n-butyl)ammonium hydrogensulfate / dichloromethane; water / 20 °C

2.1: hydrogenchloride; cyclohexene / palladium 10% on activated carbon / ethanol; water / 0.08 h / 150 °C / Microwave irradiation

3.1: ethanol / 0.08 h / 65 °C

3.2: 2 h / 70 °C

4.1: diamide; triphenylphosphine / tetrahydrofuran / 1.5 h / 150 °C / Microwave irradiation

5.1: carbonochloridic acid 1-chloro-ethyl ester; N,N,N',N'-tetramethyl-1,8-diaminonaphthalene / dichloromethane / 0.5 h / 20 °C

5.2: 2 h / Heating / reflux

With hydrogenchloride; sodium hydroxide; carbonochloridic acid 1-chloro-ethyl ester; diamide; tetra(n-butyl)ammonium hydrogensulfate; N,N,N',N'-tetramethyl-1,8-diaminonaphthalene; triphenylphosphine; cyclohexene; palladium 10% on activated carbon; In tetrahydrofuran; ethanol; dichloromethane; water;