{1-[chloro(p-tolylsulfinyl)methyl]-3,3-bis(phenylsulfanylmethyl)cyclobutyl}acetonitrile

Base Information

Chemical Name:{1-[chloro(p-tolylsulfinyl)methyl]-3,3-bis(phenylsulfanylmethyl)cyclobutyl}acetonitrile
CAS No.:938436-22-7
Molecular Formula:C₂₈H₂₈ClNOS₃
Molecular Weight:526.187
Hs Code.:

Synonyms:{1-[chloro(p-tolylsulfinyl)methyl]-3,3-bis(phenylsulfanylmethyl)cyclobutyl}acetonitrile

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Chemical Property of {1-[chloro(p-tolylsulfinyl)methyl]-3,3-bis(phenylsulfanylmethyl)cyclobutyl}acetonitrile

Chemical Property:

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Technology Process of {1-[chloro(p-tolylsulfinyl)methyl]-3,3-bis(phenylsulfanylmethyl)cyclobutyl}acetonitrile

There total 6 articles about {1-[chloro(p-tolylsulfinyl)methyl]-3,3-bis(phenylsulfanylmethyl)cyclobutyl}acetonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 938436-21-6
3,3-di[(phenylsulfanyl)methyl]-1-[chloro(p-tolylsulfinyl)methylene]cyclobutane

: 75-05-8,26809-02-9
acetonitrile

: 938436-22-7
{1-[chloro(p-tolylsulfinyl)methyl]-3,3-bis(phenylsulfanylmethyl)cyclobutyl}acetonitrile

Guidance literature:: acetonitrile; With n-butyllithium; In tetrahydrofuran; at -78 ℃;

3,3-di[(phenylsulfanyl)methyl]-1-[chloro(p-tolylsulfinyl)methylene]cyclobutane; In tetrahydrofuran; at -78 - 20 ℃; Further stages.;
DOI:10.1016/j.tet.2007.03.019

Reference yield:

: 938436-13-6
3,3-di[(phenylsulfanyl)methyl]cyclobutanone

: 938436-22-7
{1-[chloro(p-tolylsulfinyl)methyl]-3,3-bis(phenylsulfanylmethyl)cyclobutyl}acetonitrile

Guidance literature:: Multi-step reaction with 4 steps

1.1: LDA / tetrahydrofuran / -78 °C

1.2: tetrahydrofuran / -78 °C

2.1: pyridine; 4-dimethylaminopyridine / 20 °C

3.1: N-lithio-2-piperidone / tetrahydrofuran / 0 °C

4.1: n-BuLi / tetrahydrofuran / -78 °C

4.2: 94 percent / tetrahydrofuran / -78 - 20 °C

With pyridine; dmap; n-butyllithium; lithium anion of δ-valerolactam; lithium diisopropyl amide; In tetrahydrofuran;
DOI:10.1016/j.tet.2007.03.019

Reference yield:

: 938436-20-5
3,3-di[(phenylsulfanyl)methyl]cyclobutanol

: 938436-22-7
{1-[chloro(p-tolylsulfinyl)methyl]-3,3-bis(phenylsulfanylmethyl)cyclobutyl}acetonitrile

Guidance literature:: Multi-step reaction with 5 steps

1.1: 99 percent / oxalyl chloride; DMSO; triethylamine / CH₂Cl₂ / -78 - 0 °C

2.1: LDA / tetrahydrofuran / -78 °C

2.2: tetrahydrofuran / -78 °C

3.1: pyridine; 4-dimethylaminopyridine / 20 °C

4.1: N-lithio-2-piperidone / tetrahydrofuran / 0 °C

5.1: n-BuLi / tetrahydrofuran / -78 °C

5.2: 94 percent / tetrahydrofuran / -78 - 20 °C

With pyridine; dmap; n-butyllithium; oxalyl dichloride; dimethyl sulfoxide; triethylamine; lithium anion of δ-valerolactam; lithium diisopropyl amide; In tetrahydrofuran; dichloromethane; 1.1: Swern oxidation;
DOI:10.1016/j.tet.2007.03.019