3-{4-[((Z)-Tridec-2-enyl)oxymethyl]-phenyl}-propionic acid tert-butyl ester

Base Information

Chemical Name:3-{4-[((Z)-Tridec-2-enyl)oxymethyl]-phenyl}-propionic acid tert-butyl ester
CAS No.:152123-76-7
Molecular Formula:C₂₇H₄₄O₃
Molecular Weight:416.645
Hs Code.:

Synonyms:3-{4-[((Z)-Tridec-2-enyl)oxymethyl]-phenyl}-propionic acid tert-butyl ester

Suppliers and Price of 3-{4-[((Z)-Tridec-2-enyl)oxymethyl]-phenyl}-propionic acid tert-butyl ester

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 3-{4-[((Z)-Tridec-2-enyl)oxymethyl]-phenyl}-propionic acid tert-butyl ester

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of 3-{4-[((Z)-Tridec-2-enyl)oxymethyl]-phenyl}-propionic acid tert-butyl ester

There total 9 articles about 3-{4-[((Z)-Tridec-2-enyl)oxymethyl]-phenyl}-propionic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 2050-77-3
Iododecane

: 152123-76-7
3-{4-[((Z)-Tridec-2-enyl)oxymethyl]-phenyl}-propionic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 7 steps

1: n-BuLi, hexamethylphosphoramide / tetrahydrofuran / 1 h / 0 °C

2: p-TsOH / methanol / 25 °C

3: H₂ / Pd/CaCO₃, Pb / ethyl acetate / 10 h / 25 °C

4: 1.) NaH / 1.) THF, from 0 deg C to RT, 35 min, 2.) THF, 25 deg C, 12 h

5: 98 percent / 50percent aq. HF / acetonitrile / 0.25 h / Ambient temperature

6: 93 percent / Ph₃P, imidazole, I₂ / diethyl ether; acetonitrile / 1 h / 25 °C

7: 1.) LDA / 1.) THF, -78 deg C, 30 min, 2.) THF, -78 deg C, 1 h

With 1H-imidazole; N,N,N,N,N,N-hexamethylphosphoric triamide; n-butyllithium; hydrogen fluoride; hydrogen; iodine; sodium hydride; toluene-4-sulfonic acid; triphenylphosphine; lithium diisopropyl amide; Lindlar's catalyst; Piperonyl butoxide; In tetrahydrofuran; methanol; diethyl ether; ethyl acetate; acetonitrile;
DOI:10.1021/jm9606047

Reference yield:

: 51887-25-3
tridec-2-yn-1-ol

: 152123-76-7
3-{4-[((Z)-Tridec-2-enyl)oxymethyl]-phenyl}-propionic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: H₂ / Pd/CaCO₃, Pb / ethyl acetate / 10 h / 25 °C

2: 1.) NaH / 1.) THF, from 0 deg C to RT, 35 min, 2.) THF, 25 deg C, 12 h

3: 98 percent / 50percent aq. HF / acetonitrile / 0.25 h / Ambient temperature

4: 93 percent / Ph₃P, imidazole, I₂ / diethyl ether; acetonitrile / 1 h / 25 °C

5: 1.) LDA / 1.) THF, -78 deg C, 30 min, 2.) THF, -78 deg C, 1 h

With 1H-imidazole; hydrogen fluoride; hydrogen; iodine; sodium hydride; triphenylphosphine; lithium diisopropyl amide; Lindlar's catalyst; Piperonyl butoxide; In diethyl ether; ethyl acetate; acetonitrile;
DOI:10.1021/jm9606047

Reference yield:

: 108604-32-6
2-(tridec-2-yn-1-yloxy)tetrahydro-2H-pyran

: 152123-76-7
3-{4-[((Z)-Tridec-2-enyl)oxymethyl]-phenyl}-propionic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: p-TsOH / methanol / 25 °C

2: H₂ / Pd/CaCO₃, Pb / ethyl acetate / 10 h / 25 °C

3: 1.) NaH / 1.) THF, from 0 deg C to RT, 35 min, 2.) THF, 25 deg C, 12 h

4: 98 percent / 50percent aq. HF / acetonitrile / 0.25 h / Ambient temperature

5: 93 percent / Ph₃P, imidazole, I₂ / diethyl ether; acetonitrile / 1 h / 25 °C

6: 1.) LDA / 1.) THF, -78 deg C, 30 min, 2.) THF, -78 deg C, 1 h

With 1H-imidazole; hydrogen fluoride; hydrogen; iodine; sodium hydride; toluene-4-sulfonic acid; triphenylphosphine; lithium diisopropyl amide; Lindlar's catalyst; Piperonyl butoxide; In methanol; diethyl ether; ethyl acetate; acetonitrile;
DOI:10.1021/jm9606047