benzyl 6-<3-(1-adamantyl)-4-<<(trifluoromethyl)sulfonyl>oxy>phenyl>-2-naphthoate

Base Information

Chemical Name:benzyl 6-<3-(1-adamantyl)-4-<<(trifluoromethyl)sulfonyl>oxy>phenyl>-2-naphthoate
CAS No.:146966-06-5
Molecular Formula:C₃₅H₃₁F₃O₅S
Molecular Weight:620.689
Hs Code.:

Synonyms:benzyl 6-<3-(1-adamantyl)-4-<<(trifluoromethyl)sulfonyl>oxy>phenyl>-2-naphthoate

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Chemical Property of benzyl 6-<3-(1-adamantyl)-4-<<(trifluoromethyl)sulfonyl>oxy>phenyl>-2-naphthoate

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Technology Process of benzyl 6-<3-(1-adamantyl)-4-<<(trifluoromethyl)sulfonyl>oxy>phenyl>-2-naphthoate

There total 9 articles about benzyl 6-<3-(1-adamantyl)-4-<<(trifluoromethyl)sulfonyl>oxy>phenyl>-2-naphthoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 358-23-6
trifluoromethylsulfonic anhydride

: 146966-03-2
benzyl 6-<3-(1-adamantyl)-4-hydroxyphenyl>-2-naphthoate

: 146966-06-5
benzyl 6-<3-(1-adamantyl)-4-<<(trifluoromethyl)sulfonyl>oxy>phenyl>-2-naphthoate

Guidance literature:: With pyridine; dmap; In dichloromethane; at -70 ℃;
DOI:10.1021/jm00026a006

Reference yield:

: 358-23-6
trifluoromethylsulfonic anhydride

: 108-95-2,27073-41-2
phenol

: 146966-06-5
benzyl 6-<3-(1-adamantyl)-4-<<(trifluoromethyl)sulfonyl>oxy>phenyl>-2-naphthoate

Guidance literature:: With pyridine; 2-(Dimethylamino)pyridine; In hexane; dichloromethane;

Reference yield:

: 106-41-2
4-bromo-phenol

: 146966-06-5
benzyl 6-<3-(1-adamantyl)-4-<<(trifluoromethyl)sulfonyl>oxy>phenyl>-2-naphthoate

Guidance literature:: Multi-step reaction with 7 steps

1: 86 percent / conc. H₂SO₄ / CH₂Cl₂ / 8 h / Ambient temperature

2: 86 percent / Et₃N, 4-(N,N-dimethylamino)pyridine / dimethylformamide / 4 h / Ambient temperature

3: 1.) Mg, I₂, 2.) ZnCl₂, 3.) NiCl₂*1,2-bis(diphenylphosphino)ethane

4: 99 percent / 1.1 M tetrabutylammonium fluoride / tetrahydrofuran / 1.5 h / Ambient temperature

5: 79 percent / 2 N NaOH / methanol / 8 h / Heating

6: 1.) NaH / 1.) DMF, RT, 1 h, 2.) DMF, 20 deg C, 2 h

7: 89 percent / pyridine, 4-(N,N-dimethylamino)pyridine / CH₂Cl₂ / -70 °C

With pyridine; dmap; sodium hydroxide; 1,2-bis(diphenylphosphino)ethane nickel(II) chloride; sulfuric acid; tetrabutyl ammonium fluoride; iodine; sodium hydride; magnesium; triethylamine; zinc(II) chloride; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm00026a006