{5-[(S)-3-Amino-3-(3-fluorophenyl)-propyl]hexahydropyrrolo[3,4-c]pyrrol-2-yl}-(4,6-dimethylpyrimidin-5-yl)methanone

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Chemical Name:{5-[(S)-3-Amino-3-(3-fluorophenyl)-propyl]hexahydropyrrolo[3,4-c]pyrrol-2-yl}-(4,6-dimethylpyrimidin-5-yl)methanone
CAS No.:872001-57-5
Molecular Formula:C₂₂H₂₈FN₅O
Molecular Weight:397.496
Hs Code.:

Synonyms:{5-[(S)-3-Amino-3-(3-fluorophenyl)-propyl]hexahydropyrrolo[3,4-c]pyrrol-2-yl}-(4,6-dimethylpyrimidin-5-yl)methanone

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Chemical Property of {5-[(S)-3-Amino-3-(3-fluorophenyl)-propyl]hexahydropyrrolo[3,4-c]pyrrol-2-yl}-(4,6-dimethylpyrimidin-5-yl)methanone

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Technology Process of {5-[(S)-3-Amino-3-(3-fluorophenyl)-propyl]hexahydropyrrolo[3,4-c]pyrrol-2-yl}-(4,6-dimethylpyrimidin-5-yl)methanone

There total 15 articles about {5-[(S)-3-Amino-3-(3-fluorophenyl)-propyl]hexahydropyrrolo[3,4-c]pyrrol-2-yl}-(4,6-dimethylpyrimidin-5-yl)methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 872001-56-4
[(S)-3-[5-(4,6-Dimethylpyrimidine-5-carbonyl)hexahydropyrrolo[3,4-c]pyrrol-2-yl]-1-(3-fluorophenyl)propyl]carbamic acid tert-butyl ester

: 872001-57-5
{5-[(S)-3-Amino-3-(3-fluorophenyl)-propyl]hexahydropyrrolo[3,4-c]pyrrol-2-yl}-(4,6-dimethylpyrimidin-5-yl)methanone

Guidance literature:: With hydrogenchloride; In toluene; at 25 - 35 ℃;
DOI:10.1021/op100020z

Reference yield:

: 1220514-62-4
(S)-3-tert-butoxycfarbonylamino-3-(3-fluorophenyl)propionic acid ethyl ester

: 872001-57-5
{5-[(S)-3-Amino-3-(3-fluorophenyl)-propyl]hexahydropyrrolo[3,4-c]pyrrol-2-yl}-(4,6-dimethylpyrimidin-5-yl)methanone

Guidance literature:: Multi-step reaction with 4 steps

1: sodium bis(2-methoxyethoxy)aluminium dihydride / 2-methyltetrahydrofuran; toluene / 0 - 24 °C / Large scale reaction

2: pyridine; sulfur trioxide pyridine complex; dimethyl sulfoxide; triethylamine / dichloromethane / 0 - 20 °C

3: sodium tris(acetoxy)borohydride / dichloromethane / 10 - 60 °C

4: hydrogenchloride / toluene / 25 - 35 °C

With pyridine; hydrogenchloride; sulfur trioxide pyridine complex; sodium tris(acetoxy)borohydride; dimethyl sulfoxide; triethylamine; sodium bis(2-methoxyethoxy)aluminium dihydride; In 2-methyltetrahydrofuran; dichloromethane; toluene; 2: Parikh-Doering oxidation;
DOI:10.1021/op100020z

Reference yield:

: 172739-04-7
cis-3-benzyl-3,7-diazabicyclo[3.3.0]octane

: 872001-57-5
{5-[(S)-3-Amino-3-(3-fluorophenyl)-propyl]hexahydropyrrolo[3,4-c]pyrrol-2-yl}-(4,6-dimethylpyrimidin-5-yl)methanone

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium phosphate; dipotassium hydrogenphosphate / water; acetonitrile / 2 h / 0 °C / Large scale reaction

1.2: 10 °C / Large scale reaction

2.1: palladium 10% on activated carbon; hydrogen / methabol / 60 °C / 5931.67 Torr

3.1: sodium tris(acetoxy)borohydride / dichloromethane / 10 - 60 °C

4.1: hydrogenchloride / toluene / 25 - 35 °C

With hydrogenchloride; potassium phosphate; dipotassium hydrogenphosphate; palladium 10% on activated carbon; hydrogen; sodium tris(acetoxy)borohydride; In dichloromethane; methabol; water; toluene; acetonitrile;
DOI:10.1021/op100020z