4-(4-(4-chlorophenyl)-2-(piperidine-1-carbonyl)thiazol-5-yl)-3-fluorobenzenesulfonamide

Base Information

Chemical Name:4-(4-(4-chlorophenyl)-2-(piperidine-1-carbonyl)thiazol-5-yl)-3-fluorobenzenesulfonamide
CAS No.:1454649-62-7
Molecular Formula:C₂₁H₁₉ClFN₃O₃S₂
Molecular Weight:479.984
Hs Code.:

Synonyms:4-(4-(4-chlorophenyl)-2-(piperidine-1-carbonyl)thiazol-5-yl)-3-fluorobenzenesulfonamide

Suppliers and Price of 4-(4-(4-chlorophenyl)-2-(piperidine-1-carbonyl)thiazol-5-yl)-3-fluorobenzenesulfonamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 4-(4-(4-chlorophenyl)-2-(piperidine-1-carbonyl)thiazol-5-yl)-3-fluorobenzenesulfonamide

Chemical Property:

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Technology Process of 4-(4-(4-chlorophenyl)-2-(piperidine-1-carbonyl)thiazol-5-yl)-3-fluorobenzenesulfonamide

There total 2 articles about 4-(4-(4-chlorophenyl)-2-(piperidine-1-carbonyl)thiazol-5-yl)-3-fluorobenzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 29.8%

: 263349-73-1
4-bromo-3-fluorobenzenesulfonamide

: 1454650-30-6
(4-(4-chlorophenyl)thiazol-2-yl)(piperidin-1-yl)methanone

: 1454649-62-7
4-(4-(4-chlorophenyl)-2-(piperidine-1-carbonyl)thiazol-5-yl)-3-fluorobenzenesulfonamide

Guidance literature:: With potassium acetate; palladium diacetate; In N,N-dimethyl acetamide; at 150 ℃; for 15h; Inert atmosphere; Sealed tube;

Reference yield:

: 110-89-4
piperidine

: 779320-20-6
4-(4-chlorophenyl)thiazole-2-carboxylic acid

: 1454649-62-7
4-(4-(4-chlorophenyl)-2-(piperidine-1-carbonyl)thiazol-5-yl)-3-fluorobenzenesulfonamide

Guidance literature:: Multi-step reaction with 2 steps

1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / N,N-dimethyl-formamide / 15 h / 20 °C

2: potassium acetate; palladium diacetate / N,N-dimethyl acetamide / 15 h / 150 °C / Inert atmosphere; Sealed tube

With potassium acetate; palladium diacetate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In N,N-dimethyl acetamide; N,N-dimethyl-formamide;