4'-Chloro-3,4-dihydroxybenzophenone

Base Information

• Chemical Name: 4'-Chloro-3,4-dihydroxybenzophenone
• CAS No.: 134612-84-3
• Molecular Formula: C13H9ClO3
• Molecular Weight: 248.66
• Hs Code.: 2914700090
• Mol file: 134612-84-3.mol

Synonyms:(4-Chlorophenyl)(3,4-dihydroxyphenyl)methanone;

Chemical Property of 4'-Chloro-3,4-dihydroxybenzophenone

Chemical Property:

• Melting Point: 190°C
• Boiling Point: 468.771 °C at 760 mmHg
• PKA: 7.56±0.20(Predicted)
• Flash Point: 237.304 °C
• PSA: 57.53000
• Density: 1.41 g/cm³
• LogP: 2.98220
• Storage Temp.: Inert atmosphere,Room Temperature

Purity/Quality:

99% ^*data from raw suppliers

(4-Chlorophenyl)(3,4-dihydroxyphenyl)methanone 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: (4-Chlorophenyl)(3,4-dihydroxyphenyl)methanone is used because it showed inhibitory activity against protein tyrosine kinase as detected by structure-activity relationship.

Technology Process of 4'-Chloro-3,4-dihydroxybenzophenone

There total 2 articles about 4'-Chloro-3,4-dihydroxybenzophenone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-chloro-3',4'-dimethoxy benzophenone (116412-83-0) → 4-chloro-3',4'-dihydroxydiphenylmethanone (134612-84-3)

Guidance literature:

With boron tribromide; In dichloromethane; at -78 - 20 ℃; for 4h;

DOI:10.1016/j.bmcl.2010.05.068

Reference yield:

4'-chloro-4-hydroxy-3-methoxybenzophenone (134612-37-6) → 4-chloro-3',4'-dihydroxydiphenylmethanone (134612-84-3)

Guidance literature:

upstream raw materials:

4'-chloro-4-hydroxy-3-methoxybenzophenone

4-chloro-3',4'-dimethoxy benzophenone

Refernces

• 1、 -. "Catechol derivatives". . . Retrieved 2008/06/13.