N-{3-[5-Ethyl-2-propyl-3-(2'-sulfamoyl-biphenyl-4-ylmethyl)-3H-imidazol-4-yl]-3-oxo-propyl}-N-pyridin-3-yl-nicotinamide

Base Information

Chemical Name:N-{3-[5-Ethyl-2-propyl-3-(2'-sulfamoyl-biphenyl-4-ylmethyl)-3H-imidazol-4-yl]-3-oxo-propyl}-N-pyridin-3-yl-nicotinamide
CAS No.:1028260-07-2
Molecular Formula:C₃₅H₃₆N₆O₄S
Molecular Weight:636.775
Hs Code.:

Synonyms:N-{3-[5-Ethyl-2-propyl-3-(2'-sulfamoyl-biphenyl-4-ylmethyl)-3H-imidazol-4-yl]-3-oxo-propyl}-N-pyridin-3-yl-nicotinamide

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Chemical Property of N-{3-[5-Ethyl-2-propyl-3-(2'-sulfamoyl-biphenyl-4-ylmethyl)-3H-imidazol-4-yl]-3-oxo-propyl}-N-pyridin-3-yl-nicotinamide

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Technology Process of N-{3-[5-Ethyl-2-propyl-3-(2'-sulfamoyl-biphenyl-4-ylmethyl)-3H-imidazol-4-yl]-3-oxo-propyl}-N-pyridin-3-yl-nicotinamide

There total 8 articles about N-{3-[5-Ethyl-2-propyl-3-(2'-sulfamoyl-biphenyl-4-ylmethyl)-3H-imidazol-4-yl]-3-oxo-propyl}-N-pyridin-3-yl-nicotinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 462-08-8
pyridin-3-ylamine

: 1028260-07-2
N-{3-[5-Ethyl-2-propyl-3-(2'-sulfamoyl-biphenyl-4-ylmethyl)-3H-imidazol-4-yl]-3-oxo-propyl}-N-pyridin-3-yl-nicotinamide

Guidance literature:: Multi-step reaction with 3 steps

1: Et₃N / tetrahydrofuran / Heating

2: Et₃N / tetrahydrofuran / Heating

3: TFA

With triethylamine; trifluoroacetic acid; In tetrahydrofuran;
DOI:10.1021/jm00015a016

Reference yield:

: 51436-99-8
2-fluoro-4-bromotoluene

: 1028260-07-2
N-{3-[5-Ethyl-2-propyl-3-(2'-sulfamoyl-biphenyl-4-ylmethyl)-3H-imidazol-4-yl]-3-oxo-propyl}-N-pyridin-3-yl-nicotinamide

Guidance literature:: Multi-step reaction with 8 steps

1: NBS, AIBN / CCl₄ / 4 h / Heating

2: K₂CO₃ / dimethylformamide / 12 h / Ambient temperature

3: 86 percent / aq. Na₂CO₃, (PPh₃)4Pd, tetrabutylammonium bromide / toluene / 20 h / Heating

4: tetrahydrofuran / 1.5 h / Ambient temperature

5: MnO₂ / CH₂Cl₂ / 24 h / Ambient temperature

6: Et₃N / tetrahydrofuran / Heating

7: Et₃N / tetrahydrofuran / Heating

8: TFA

With manganese(IV) oxide; N-Bromosuccinimide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; 2,2'-azobis(isobutyronitrile); tetrabutylammomium bromide; sodium carbonate; potassium carbonate; triethylamine; trifluoroacetic acid; In tetrahydrofuran; tetrachloromethane; dichloromethane; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jm00015a016

Reference yield:

: 76283-09-5
4-bromo-2-fluorobenzyl bromide

: 1028260-07-2
N-{3-[5-Ethyl-2-propyl-3-(2'-sulfamoyl-biphenyl-4-ylmethyl)-3H-imidazol-4-yl]-3-oxo-propyl}-N-pyridin-3-yl-nicotinamide

Guidance literature:: Multi-step reaction with 7 steps

1: K₂CO₃ / dimethylformamide / 12 h / Ambient temperature

2: 86 percent / aq. Na₂CO₃, (PPh₃)4Pd, tetrabutylammonium bromide / toluene / 20 h / Heating

3: tetrahydrofuran / 1.5 h / Ambient temperature

4: MnO₂ / CH₂Cl₂ / 24 h / Ambient temperature

5: Et₃N / tetrahydrofuran / Heating

6: Et₃N / tetrahydrofuran / Heating

7: TFA

With manganese(IV) oxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; tetrabutylammomium bromide; sodium carbonate; potassium carbonate; triethylamine; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jm00015a016