(Z)-5-(2,4-difluorobenzylidene)-3-(2-(dimethylamino)ethyl)-2-thioxo-4-thiazolidinone

Base Information

• Chemical Name: (Z)-5-(2,4-difluorobenzylidene)-3-(2-(dimethylamino)ethyl)-2-thioxo-4-thiazolidinone
• CAS No.: 1314887-73-4
• Molecular Formula: C₁₄H₁₄F₂N₂OS₂
• Molecular Weight: 328.407
• Mol file: 1314887-73-4.mol

Synonyms:(Z)-5-(2,4-difluorobenzylidene)-3-(2-(dimethylamino)ethyl)-2-thioxo-4-thiazolidinone

Chemical Property of (Z)-5-(2,4-difluorobenzylidene)-3-(2-(dimethylamino)ethyl)-2-thioxo-4-thiazolidinone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (Z)-5-(2,4-difluorobenzylidene)-3-(2-(dimethylamino)ethyl)-2-thioxo-4-thiazolidinone

There total 2 articles about (Z)-5-(2,4-difluorobenzylidene)-3-(2-(dimethylamino)ethyl)-2-thioxo-4-thiazolidinone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

3-(2-(dimethylamino)ethyl)-2-thioxo-4-thiazolidinone (46007-39-0) + 2,4-difluorobenzaldehyde (1550-35-2) → (Z)-5-(2,4-difluorobenzylidene)-3-(2-(dimethylamino)ethyl)-2-thioxo-4-thiazolidinone (1314887-73-4)

Guidance literature:

With piperidine; Reflux;

DOI:10.1016/j.ejmech.2011.05.017

Reference yield:

C5H12N2S2*C6H15N → (Z)-5-(2,4-difluorobenzylidene)-3-(2-(dimethylamino)ethyl)-2-thioxo-4-thiazolidinone (1314887-73-4)

Guidance literature:

Multi-step reaction with 2 steps

1.1: potassium carbonate / methanol; water / 25 °C

1.2: 12 h / 35 - 40 °C / pH 4

2.1: piperidine / Reflux

With piperidine; potassium carbonate; In methanol; water; 2.1: Knoevenagel condensation;

DOI:10.1016/j.ejmech.2011.05.017

Reference yield:

(Z)-5-(2,4-difluorobenzylidene)-3-(2-(dimethylamino)ethyl)-2-thioxo-4-thiazolidinone (1314887-73-4) + orthoformic acid triethyl ester (122-51-0) → BF4(1-)*C16H19F2N2OS2(1+)

Guidance literature:

With boron trifluoride diethyl etherate; In 1,4-dioxane; at 80 ℃; for 4h;

DOI:10.1016/j.ejmech.2011.05.017

upstream raw materials:

3-(2-(dimethylamino)ethyl)-2-thioxo-4-thiazolidinone

2,4-difluorobenzaldehyde