{2-[4-(2-methyl-[1,3]dioxolan-2-yl)-butyl]-oxazol-4-yl}-carbamic acid 2-chloro-benzyl ester

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Chemical Name:{2-[4-(2-methyl-[1,3]dioxolan-2-yl)-butyl]-oxazol-4-yl}-carbamic acid 2-chloro-benzyl ester
CAS No.:1258458-68-2
Molecular Formula:C₁₉H₂₃ClN₂O₅
Molecular Weight:394.855
Hs Code.:

Synonyms:{2-[4-(2-methyl-[1,3]dioxolan-2-yl)-butyl]-oxazol-4-yl}-carbamic acid 2-chloro-benzyl ester

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Chemical Property of {2-[4-(2-methyl-[1,3]dioxolan-2-yl)-butyl]-oxazol-4-yl}-carbamic acid 2-chloro-benzyl ester

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Technology Process of {2-[4-(2-methyl-[1,3]dioxolan-2-yl)-butyl]-oxazol-4-yl}-carbamic acid 2-chloro-benzyl ester

There total 10 articles about {2-[4-(2-methyl-[1,3]dioxolan-2-yl)-butyl]-oxazol-4-yl}-carbamic acid 2-chloro-benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 17849-38-6
2-Chlorobenzyl alcohol

: 1258458-66-0
2-[4-(2-methyl-[1,3]dioxolan-2-yl)-butyl]-oxazole-4-carbonyl azide

: 1258458-68-2
{2-[4-(2-methyl-[1,3]dioxolan-2-yl)-butyl]-oxazol-4-yl}-carbamic acid 2-chloro-benzyl ester

Guidance literature:: 2-[4-(2-methyl-[1,3]dioxolan-2-yl)-butyl]-oxazole-4-carbonyl azide; In xylene; at 140 ℃; for 0.0833333h; Inert atmosphere;

2-Chlorobenzyl alcohol; In xylene; at 140 ℃; for 0.0833333h; Inert atmosphere;

Reference yield:

: 3128-07-2
6-oxoheptanoic acid

: 1258458-68-2
{2-[4-(2-methyl-[1,3]dioxolan-2-yl)-butyl]-oxazol-4-yl}-carbamic acid 2-chloro-benzyl ester

Guidance literature:: Multi-step reaction with 10 steps

1.1: sulfuric acid / dichloromethane / 24 h / Inert atmosphere; Reflux

2.1: lithium tetrafluoroborate / ethylene glycol / 14 h / 95 °C / Inert atmosphere

3.1: water; lithium hydroxide monohydrate / tetrahydrofuran / 3 h / 20 °C / Inert atmosphere

3.2: pH 4 - 5 / Cooling

4.1: triethylamine; isobutyl chloroformate / tetrahydrofuran / 1 h / -30 °C / Inert atmosphere

4.2: 19 h / -30 - 20 °C / Inert atmosphere

5.1: methoxycarbonylsulfamoyl-triethylammmonium hydroxide / tetrahydrofuran / -10 - 0 °C / Inert atmosphere; Reflux

6.1: Bromotrichloromethane; 1,8-diazabicyclo[5.4.0]undec-7-ene / dichloromethane / 0 - 20 °C / Inert atmosphere

7.1: sodium hydroxide; water / tetrahydrofuran / 1 h / 20 °C / Inert atmosphere

7.2: pH 4 - 5

8.1: oxalyl dichloride / N,N-dimethyl-formamide / toluene / 1 h / 20 °C / Inert atmosphere

9.1: sodium azide / water; acetone / 3.25 h / 0 - 20 °C / Inert atmosphere

10.1: xylene / 0.08 h / 140 °C / Inert atmosphere

10.2: 0.08 h / 140 °C / Inert atmosphere

With lithium tetrafluoroborate; sodium azide; methoxycarbonylsulfamoyl-triethylammmonium hydroxide; oxalyl dichloride; lithium hydroxide monohydrate; Bromotrichloromethane; water; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; sodium hydroxide; isobutyl chloroformate; sulfuric acid; N,N-dimethyl-formamide; In tetrahydrofuran; dichloromethane; water; ethylene glycol; acetone; toluene; xylene; 10.1: Curtius Rearrangement;

Reference yield:

: 2046-21-1
methyl 6-oxoheptanoate

: 1258458-68-2
{2-[4-(2-methyl-[1,3]dioxolan-2-yl)-butyl]-oxazol-4-yl}-carbamic acid 2-chloro-benzyl ester

Guidance literature:: Multi-step reaction with 9 steps

1.1: lithium tetrafluoroborate / ethylene glycol / 14 h / 95 °C / Inert atmosphere

2.1: water; lithium hydroxide monohydrate / tetrahydrofuran / 3 h / 20 °C / Inert atmosphere

2.2: pH 4 - 5 / Cooling

3.1: triethylamine; isobutyl chloroformate / tetrahydrofuran / 1 h / -30 °C / Inert atmosphere

3.2: 19 h / -30 - 20 °C / Inert atmosphere

4.1: methoxycarbonylsulfamoyl-triethylammmonium hydroxide / tetrahydrofuran / -10 - 0 °C / Inert atmosphere; Reflux

5.1: Bromotrichloromethane; 1,8-diazabicyclo[5.4.0]undec-7-ene / dichloromethane / 0 - 20 °C / Inert atmosphere

6.1: sodium hydroxide; water / tetrahydrofuran / 1 h / 20 °C / Inert atmosphere

6.2: pH 4 - 5

7.1: oxalyl dichloride / N,N-dimethyl-formamide / toluene / 1 h / 20 °C / Inert atmosphere

8.1: sodium azide / water; acetone / 3.25 h / 0 - 20 °C / Inert atmosphere

9.1: xylene / 0.08 h / 140 °C / Inert atmosphere

9.2: 0.08 h / 140 °C / Inert atmosphere

With lithium tetrafluoroborate; sodium azide; methoxycarbonylsulfamoyl-triethylammmonium hydroxide; oxalyl dichloride; lithium hydroxide monohydrate; Bromotrichloromethane; water; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; sodium hydroxide; isobutyl chloroformate; N,N-dimethyl-formamide; In tetrahydrofuran; dichloromethane; water; ethylene glycol; acetone; toluene; xylene; 9.1: Curtius Rearrangement;