Technology Process of (3R,5R,6S)-tert-butyl 2-oxo-3-(2-oxoethyl)-5,6-diphenyl-3-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-butyl)morpholine-4-carboxylate
There total 5 articles about (3R,5R,6S)-tert-butyl 2-oxo-3-(2-oxoethyl)-5,6-diphenyl-3-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-butyl)morpholine-4-carboxylate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
ozone; triphenylphosphine;
In
dichloromethane;
for 16h;
DOI:10.1021/jm400014c
- Guidance literature:
-
Multi-step reaction with 2 steps
1: N,N,N,N,-tetramethylethylenediamine; potassium hexamethylsilazane / tetrahydrofuran; 1,2-dimethoxyethane / -78 °C / Inert atmosphere
2: ozone; triphenylphosphine / dichloromethane / 16 h
With
N,N,N,N,-tetramethylethylenediamine; potassium hexamethylsilazane; ozone; triphenylphosphine;
In
tetrahydrofuran; 1,2-dimethoxyethane; dichloromethane;
DOI:10.1021/jm400014c
- Guidance literature:
-
Multi-step reaction with 4 steps
1: sodium iodide / acetone / 55 °C / Inert atmosphere
2: N,N,N,N,N,N-hexamethylphosphoric triamide; sodium hexamethyldisilazane / tetrahydrofuran / -78 - 20 °C / Inert atmosphere
3: N,N,N,N,-tetramethylethylenediamine; potassium hexamethylsilazane / tetrahydrofuran; 1,2-dimethoxyethane / -78 °C / Inert atmosphere
4: ozone; triphenylphosphine / dichloromethane / 16 h
With
N,N,N,N,N,N-hexamethylphosphoric triamide; N,N,N,N,-tetramethylethylenediamine; sodium hexamethyldisilazane; potassium hexamethylsilazane; ozone; triphenylphosphine; sodium iodide;
In
tetrahydrofuran; 1,2-dimethoxyethane; dichloromethane; acetone;
DOI:10.1021/jm400014c
