4-(3-acrloyloxymethyl)-4-nitrophenoxybutanoic acid

Base Information

Chemical Name:4-(3-acrloyloxymethyl)-4-nitrophenoxybutanoic acid
CAS No.:1392043-89-8
Molecular Formula:C₁₄H₁₅NO₇
Molecular Weight:309.276
Hs Code.:

Synonyms:4-(3-acrloyloxymethyl)-4-nitrophenoxybutanoic acid

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Chemical Property of 4-(3-acrloyloxymethyl)-4-nitrophenoxybutanoic acid

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Technology Process of 4-(3-acrloyloxymethyl)-4-nitrophenoxybutanoic acid

There total 6 articles about 4-(3-acrloyloxymethyl)-4-nitrophenoxybutanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 4-(3-hydroxymethyl-4-nitrophenoxy)butanoic acid

: 814-68-6,25189-84-8
acryloyl chloride

: 1392043-89-8
4-(3-acrloyloxymethyl)-4-nitrophenoxybutanoic acid

Guidance literature:: 4-(3-hydroxymethyl-4-nitrophenoxy)butanoic acid; acryloyl chloride; With triethylamine; In tetrahydrofuran; at 0 ℃; for 24h; Inert atmosphere;

In water; at 0 - 20 ℃; for 2h; Inert atmosphere;
DOI:10.1021/ja305280w

Reference yield:

: 42454-06-8
2-nitro-5-hydroxybenzaldehyde

: 1392043-89-8
4-(3-acrloyloxymethyl)-4-nitrophenoxybutanoic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 12 h / Inert atmosphere

2.1: trifluoroacetic acid / water / 2 h / 20 - 90 °C / Inert atmosphere

3.1: sodium tetrahydroborate / 12 h / 0 - 20 °C / Inert atmosphere

4.1: triethylamine / tetrahydrofuran / 24 h / 0 °C / Inert atmosphere

4.2: 2 h / 0 - 20 °C / Inert atmosphere

With sodium tetrahydroborate; potassium carbonate; triethylamine; trifluoroacetic acid; In tetrahydrofuran; water; N,N-dimethyl-formamide;
DOI:10.1021/ja305280w

Reference yield:

: 94193-35-8
ethyl 4-((3-formyl-4-nitrophenyl)oxy)butyrate

: 1392043-89-8
4-(3-acrloyloxymethyl)-4-nitrophenoxybutanoic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: trifluoroacetic acid / water / 2 h / 20 - 90 °C / Inert atmosphere

2.1: sodium tetrahydroborate / 12 h / 0 - 20 °C / Inert atmosphere

3.1: triethylamine / tetrahydrofuran / 24 h / 0 °C / Inert atmosphere

3.2: 2 h / 0 - 20 °C / Inert atmosphere

With sodium tetrahydroborate; triethylamine; trifluoroacetic acid; In tetrahydrofuran; water;
DOI:10.1021/ja305280w