methyl N-<2(S)-hydroxy-4-methylpentyl>-glycyl-L-valyl-L-phenylalaninate hydrochloride

Base Information

Chemical Name:methyl N-<2(S)-hydroxy-4-methylpentyl>-glycyl-L-valyl-L-phenylalaninate hydrochloride
CAS No.:117249-03-3
Molecular Formula:C₂₃H₃₇N₃O₅*ClH
Molecular Weight:472.025
Hs Code.:

Synonyms:methyl N-<2(S)-hydroxy-4-methylpentyl>-glycyl-L-valyl-L-phenylalaninate hydrochloride

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Chemical Property of methyl N-<2(S)-hydroxy-4-methylpentyl>-glycyl-L-valyl-L-phenylalaninate hydrochloride

Chemical Property:

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Technology Process of methyl N-<2(S)-hydroxy-4-methylpentyl>-glycyl-L-valyl-L-phenylalaninate hydrochloride

There total 6 articles about methyl N-<2(S)-hydroxy-4-methylpentyl>-glycyl-L-valyl-L-phenylalaninate hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 117175-38-9
methyl N-<2(S)-benzyloxy-4-methylpentyl>glycyl-L-valyl-L-phenylalaninate

: 117249-03-3
methyl N-<2(S)-hydroxy-4-methylpentyl>-glycyl-L-valyl-L-phenylalaninate hydrochloride

Guidance literature:: With hydrogen; hydrogenchloride; palladium on activated charcoal; In methanol; for 4h; under 2068.6 Torr; Ambient temperature;
DOI:10.1016/0223-5234(88)90171-7

Reference yield:

: 13748-90-8,498-36-2
(S)-2-hydroxyl-3,3-dimethylbutyric acid

: 117249-03-3
methyl N-<2(S)-hydroxy-4-methylpentyl>-glycyl-L-valyl-L-phenylalaninate hydrochloride

Guidance literature:: Multi-step reaction with 6 steps

1: 93.4 percent / diethyl ether / 0 °C

2: 85 percent / Ag₂O / diethyl ether / 2 h / Heating

3: 76 percent / LiAlH₄ / tetrahydrofuran / 3 h

4: 70 percent / pyridine / CH₂Cl₂ / -22 - 20 °C

5: 40 percent / CH₂Cl₂ / 2 h / Ambient temperature

6: 75 percent / hydrogen / 10percent Pd/C, aq. HCl / methanol / 4 h / 2068.6 Torr / Ambient temperature

With pyridine; lithium aluminium tetrahydride; hydrogen; silver(l) oxide; hydrogenchloride; palladium on activated charcoal; In tetrahydrofuran; methanol; diethyl ether; dichloromethane;
DOI:10.1016/0223-5234(88)90171-7

Reference yield:

: 17392-84-6
methyl (2S)-2-hydroxy-4-methylpentanoate

: 117249-03-3
methyl N-<2(S)-hydroxy-4-methylpentyl>-glycyl-L-valyl-L-phenylalaninate hydrochloride

Guidance literature:: Multi-step reaction with 5 steps

1: 85 percent / Ag₂O / diethyl ether / 2 h / Heating

2: 76 percent / LiAlH₄ / tetrahydrofuran / 3 h

3: 70 percent / pyridine / CH₂Cl₂ / -22 - 20 °C

4: 40 percent / CH₂Cl₂ / 2 h / Ambient temperature

5: 75 percent / hydrogen / 10percent Pd/C, aq. HCl / methanol / 4 h / 2068.6 Torr / Ambient temperature

With pyridine; lithium aluminium tetrahydride; hydrogen; silver(l) oxide; hydrogenchloride; palladium on activated charcoal; In tetrahydrofuran; methanol; diethyl ether; dichloromethane;
DOI:10.1016/0223-5234(88)90171-7