8-[(3,5-difluoropyridine-4-yl)methoxy]-2,6-dimethylimidazo[1,2-a]pyridine-3-carboxylic acid

Base Information

Chemical Name:8-[(3,5-difluoropyridine-4-yl)methoxy]-2,6-dimethylimidazo[1,2-a]pyridine-3-carboxylic acid
CAS No.:1609166-17-7
Molecular Formula:C₁₆H₁₃F₂N₃O₃
Molecular Weight:333.294
Hs Code.:

Synonyms:8-[(3,5-difluoropyridine-4-yl)methoxy]-2,6-dimethylimidazo[1,2-a]pyridine-3-carboxylic acid

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Chemical Property of 8-[(3,5-difluoropyridine-4-yl)methoxy]-2,6-dimethylimidazo[1,2-a]pyridine-3-carboxylic acid

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Technology Process of 8-[(3,5-difluoropyridine-4-yl)methoxy]-2,6-dimethylimidazo[1,2-a]pyridine-3-carboxylic acid

There total 11 articles about 8-[(3,5-difluoropyridine-4-yl)methoxy]-2,6-dimethylimidazo[1,2-a]pyridine-3-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 1609166-16-6
ethyl 8-[(3,5-difluoropyridine-4-yl)methoxy]-2,6-dimethylimidazo[1,2-a]pyridine-3-carboxylate

: 1609166-17-7
8-[(3,5-difluoropyridine-4-yl)methoxy]-2,6-dimethylimidazo[1,2-a]pyridine-3-carboxylic acid

Guidance literature:: With water; sodium hydroxide; In 1,4-dioxane; at 20 ℃;

Reference yield:

: 754230-78-9
3-(benzyloxy)-5-bromopyridine-2-amine

: 1609166-17-7
8-[(3,5-difluoropyridine-4-yl)methoxy]-2,6-dimethylimidazo[1,2-a]pyridine-3-carboxylic acid

Guidance literature:: Multi-step reaction with 5 steps

1: ethanol / 72 h / Inert atmosphere; Reflux; Molecular sieve

2: potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane / 8 h / Inert atmosphere; Reflux

3: hydrogen; palladium 10% on activated carbon / ethanol; dichloromethane / 20 °C / 760.05 Torr / Inert atmosphere

4: caesium carbonate / N,N-dimethyl-formamide / 60 °C

5: water; sodium hydroxide / 1,4-dioxane / 20 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium 10% on activated carbon; water; hydrogen; potassium carbonate; caesium carbonate; sodium hydroxide; In 1,4-dioxane; ethanol; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 1609082-34-9
ethyl 8-(benzyloxy)-2,6-dimethylimidazo[1,2-a] pyridine-3-carboxylate

: 1609166-17-7
8-[(3,5-difluoropyridine-4-yl)methoxy]-2,6-dimethylimidazo[1,2-a]pyridine-3-carboxylic acid

Guidance literature:: Multi-step reaction with 3 steps

1: hydrogen; palladium 10% on activated carbon / ethanol; dichloromethane / 20 °C / 760.05 Torr / Inert atmosphere

2: caesium carbonate / N,N-dimethyl-formamide / 60 °C

3: water; sodium hydroxide / 1,4-dioxane / 20 °C

With palladium 10% on activated carbon; water; hydrogen; caesium carbonate; sodium hydroxide; In 1,4-dioxane; ethanol; dichloromethane; N,N-dimethyl-formamide;