4-Chloropiperidine hydrochloride

Base Information

• Chemical Name: 4-Chloropiperidine hydrochloride
• CAS No.: 5382-19-4
• Molecular Formula: C₅H₁₀ClN*ClH
• Molecular Weight: 156.055
• Hs Code.: 2933399090
• Mol file: 5382-19-4.mol

Synonyms:Piperidine,4-chloro-, hydrochloride (7CI,8CI,9CI);Piperidine, 4-chloro-, hydrochloride (1:1);4-Chloropiperidine hydrochloride (1:1);

Chemical Property of 4-Chloropiperidine hydrochloride

Chemical Property:

• Vapor Pressure: 0.114mmHg at 25°C
• Melting Point: 200-201 °C
• Boiling Point: 216.7 °C at 760 mmHg
• Flash Point: 84.9 °C
• PSA: 12.03000
• LogP: 2.10800
• Storage Temp.: Inert atmosphere,Room Temperature
• Solubility.: Chloroform (Slightly), Ethanol (Slightly) , Methanol (Slightly)

Purity/Quality:

99.9% ^*data from raw suppliers

4-ChloropiperidineHydrochloride ^*data from reagent suppliers

Safty Information:

• Statements: 36/37/38
• Safety Statements: 26-36/37/39

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 4-Chloro-1-methylpiperidine is a reactant in the synthesis of indole and benzimidazole piperazines as histamine H4 receptor antagonist.

Technology Process of 4-Chloropiperidine hydrochloride

There total 2 articles about 4-Chloropiperidine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-chloro-1-methylpiperidine (5570-77-4) → 4-chloropiperidine hydrochloride (5382-19-4)

Guidance literature:

4-chloro-1-methylpiperidine; With carbonochloridic acid 1-chloro-ethyl ester; In 1,2-dichloro-ethane; at 80 ℃; for 3h;

In methanol; for 2h; Heating;

DOI:10.1021/jo048047g

Reference yield:

→ 4-chloropiperidine hydrochloride (5382-19-4)

Guidance literature:

upstream raw materials:

4-chloro-1-methylpiperidine

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