2-(4-{8-[(tert-butoxycarbonyl)amino]octanoyl}piperazin-1-yl)ethyl 4-amino-5-chloro-2-methoxybenzoate

Base Information

Chemical Name:2-(4-{8-[(tert-butoxycarbonyl)amino]octanoyl}piperazin-1-yl)ethyl 4-amino-5-chloro-2-methoxybenzoate
CAS No.:566906-19-2
Molecular Formula:C₂₇H₄₃ClN₄O₆
Molecular Weight:555.115
Hs Code.:

Synonyms:2-(4-{8-[(tert-butoxycarbonyl)amino]octanoyl}piperazin-1-yl)ethyl 4-amino-5-chloro-2-methoxybenzoate

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Chemical Property of 2-(4-{8-[(tert-butoxycarbonyl)amino]octanoyl}piperazin-1-yl)ethyl 4-amino-5-chloro-2-methoxybenzoate

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Technology Process of 2-(4-{8-[(tert-butoxycarbonyl)amino]octanoyl}piperazin-1-yl)ethyl 4-amino-5-chloro-2-methoxybenzoate

There total 1 articles about 2-(4-{8-[(tert-butoxycarbonyl)amino]octanoyl}piperazin-1-yl)ethyl 4-amino-5-chloro-2-methoxybenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 30100-16-4
8-tert-butoxycarbonylaminooctanoic acid

: 2-[N-piperazin-1-yl]ethyl 4-amino-5-chloro-2-methoxybenzoate hydrochloride

: 566906-19-2
2-(4-{8-[(tert-butoxycarbonyl)amino]octanoyl}piperazin-1-yl)ethyl 4-amino-5-chloro-2-methoxybenzoate

Guidance literature:: 8-tert-butoxycarbonylaminooctanoic acid; With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine; In acetonitrile; at 0 ℃;

2-[N-piperazin-1-yl]ethyl 4-amino-5-chloro-2-methoxybenzoate hydrochloride; In acetonitrile; at 20 ℃; for 24h;
DOI:10.1021/jm0307887

Reference yield: 48.0%

: 566906-19-2
2-(4-{8-[(tert-butoxycarbonyl)amino]octanoyl}piperazin-1-yl)ethyl 4-amino-5-chloro-2-methoxybenzoate

: 2-[4-(8-aminooctanoyl)piperazin-1-yl]ethyl 4-amino-5-chloro-2-methoxybenzoate dihydrochloride

Guidance literature:: With hydrogenchloride; In methanol; at 20 ℃;
DOI:10.1021/jm0307887

Reference yield:

: 566906-19-2
2-(4-{8-[(tert-butoxycarbonyl)amino]octanoyl}piperazin-1-yl)ethyl 4-amino-5-chloro-2-methoxybenzoate

: 4-amino-5-chloro-2-methoxy-benzoic acid 2-{4-[8-(5-dimethylamino-naphthalene-1-sulfonylamino)-octanoyl]-piperazin-1-yl}-ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 48 percent / HCl / methanol / 20 °C

2: 88 percent / Et₃N / CH₂Cl₂ / 6 h / -10 - 0 °C

With hydrogenchloride; triethylamine; In methanol; dichloromethane;
DOI:10.1021/jm0307887