ethyl 2-[2-methoxy-4-(methoxycarbonylmethoxy)phenyl]cyclopropanecarboxylate

Base Information

• Chemical Name: ethyl 2-[2-methoxy-4-(methoxycarbonylmethoxy)phenyl]cyclopropanecarboxylate
• CAS No.: 198897-28-8
• Molecular Formula: C₁₆H₂₀O₆
• Molecular Weight: 308.331
• Mol file: 198897-28-8.mol

Synonyms:ethyl 2-[2-methoxy-4-(methoxycarbonylmethoxy)phenyl]cyclopropanecarboxylate

Chemical Property of ethyl 2-[2-methoxy-4-(methoxycarbonylmethoxy)phenyl]cyclopropanecarboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ethyl 2-[2-methoxy-4-(methoxycarbonylmethoxy)phenyl]cyclopropanecarboxylate

There total 1 articles about ethyl 2-[2-methoxy-4-(methoxycarbonylmethoxy)phenyl]cyclopropanecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

diazomethane (186581-53-3,908094-01-9,334-88-3) + (E)-3-(3-Methoxy-4-methoxycarbonylmethoxy-phenyl)-acrylic acid ethyl ester → ethyl 2-[2-methoxy-4-(methoxycarbonylmethoxy)phenyl]cyclopropanecarboxylate (198897-28-8)

Guidance literature:

palladium diacetate;

DOI:10.1246/bcsj.70.2509

Reference yield: 96.0%

ethyl 2-[2-methoxy-4-(methoxycarbonylmethoxy)phenyl]cyclopropanecarboxylate (198897-28-8) → [4-(2-ethoxycarbonylcyclopropyl)-3-methoxyphenoxy]acetic acid (198897-29-9)

Guidance literature:

pig-liver esterase; In phosphate buffer; acetone; at 20 ℃; for 10h; pH=7.2;

DOI:10.1246/bcsj.70.2509

Reference yield:

ethyl 2-[2-methoxy-4-(methoxycarbonylmethoxy)phenyl]cyclopropanecarboxylate (198897-28-8) → ethyl 2-[4-(2-hydroxyethoxy)-2-methoxyphenyl]cyclopropanecarboxylate

Guidance literature:

Multi-step reaction with 3 steps

1: 96 percent / pig-liver esterase / aq. phosphate buffer; acetone / 10 h / 20 °C / pH 7.2

2: triethylamine / tetrahydrofuran / 0.08 h / -5 °C

3: NaBH₄ / tetrahydrofuran / 10 h / 20 °C

With sodium tetrahydroborate; triethylamine; pig-liver esterase; In tetrahydrofuran; phosphate buffer; acetone; 1: Hydrolysis / 2: Acylation / 3: Reduction;

DOI:10.1246/bcsj.70.2509

upstream raw materials:

diazomethane

Downstream raw materials:

[4-(2-ethoxycarbonylcyclopropyl)-3-methoxyphenoxy]acetic acid