N-methyl-4-[(1-methylethyl)oxy]-3-[(3-methyl-1H-pyrazolo[3,4-d]pyrimidin-4-yl)amino]benzenesulfonamide

Base Information

Chemical Name:N-methyl-4-[(1-methylethyl)oxy]-3-[(3-methyl-1H-pyrazolo[3,4-d]pyrimidin-4-yl)amino]benzenesulfonamide
CAS No.:1351087-82-5
Molecular Formula:C₁₆H₂₀N₆O₃S
Molecular Weight:376.439
Hs Code.:

Synonyms:N-methyl-4-[(1-methylethyl)oxy]-3-[(3-methyl-1H-pyrazolo[3,4-d]pyrimidin-4-yl)amino]benzenesulfonamide

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Chemical Property of N-methyl-4-[(1-methylethyl)oxy]-3-[(3-methyl-1H-pyrazolo[3,4-d]pyrimidin-4-yl)amino]benzenesulfonamide

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Technology Process of N-methyl-4-[(1-methylethyl)oxy]-3-[(3-methyl-1H-pyrazolo[3,4-d]pyrimidin-4-yl)amino]benzenesulfonamide

There total 9 articles about N-methyl-4-[(1-methylethyl)oxy]-3-[(3-methyl-1H-pyrazolo[3,4-d]pyrimidin-4-yl)amino]benzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

: 823-96-1
Trimethylboroxine

: 1351087-57-4
3-[(3-bromo-1H-pyrazolo[3,4-d]pyrimidin-4-yl)amino]-N-methyl-4-[(1-methylethyl)oxy]benzenesulfonamide

: 1351087-82-5
N-methyl-4-[(1-methylethyl)oxy]-3-[(3-methyl-1H-pyrazolo[3,4-d]pyrimidin-4-yl)amino]benzenesulfonamide

Guidance literature:: With potassium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In 1,4-dioxane; water; at 150 ℃; for 1.16667h; Microwave irradiation;

Reference yield:

: 1493-27-2,127723-77-7
ortho-nitrofluorobenzene

: 1351087-82-5
N-methyl-4-[(1-methylethyl)oxy]-3-[(3-methyl-1H-pyrazolo[3,4-d]pyrimidin-4-yl)amino]benzenesulfonamide

Guidance literature:: Multi-step reaction with 7 steps

1.1: chlorosulfonic acid / 18 h / 100 °C

2.1: triethylamine / tetrahydrofuran / 1 h / -35 °C

3.1: sodium hydride / mineral oil / 0.5 h / 20 °C

3.2: 20 °C

4.1: hydrogen / palladium on activated charcoal / ethanol / 20 °C / Inert atmosphere

5.1: N-ethyl-N,N-diisopropylamine / 1,4-dioxane / 80 °C / Sealed tube

6.1: sodium hydroxide / isopropyl alcohol; tetrahydrofuran / 0.33 h / 100 °C / Microwave irradiation

6.2: Microwave irradiation

7.1: potassium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane; water / 1.17 h / 150 °C / Microwave irradiation

With chlorosulfonic acid; hydrogen; sodium hydride; potassium carbonate; triethylamine; N-ethyl-N,N-diisopropylamine; sodium hydroxide; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; palladium on activated charcoal; In tetrahydrofuran; 1,4-dioxane; ethanol; water; isopropyl alcohol; mineral oil;

Reference yield:

: 6668-56-0
4-fluoro-3-nitrobenzene-1-sulfonyl chloride

: 1351087-82-5
N-methyl-4-[(1-methylethyl)oxy]-3-[(3-methyl-1H-pyrazolo[3,4-d]pyrimidin-4-yl)amino]benzenesulfonamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: triethylamine / tetrahydrofuran / 1 h / -35 °C

2.1: sodium hydride / mineral oil / 0.5 h / 20 °C

2.2: 20 °C

3.1: hydrogen / palladium on activated charcoal / ethanol / 20 °C / Inert atmosphere

4.1: N-ethyl-N,N-diisopropylamine / 1,4-dioxane / 80 °C / Sealed tube

5.1: sodium hydroxide / isopropyl alcohol; tetrahydrofuran / 0.33 h / 100 °C / Microwave irradiation

5.2: Microwave irradiation

6.1: potassium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane; water / 1.17 h / 150 °C / Microwave irradiation

With hydrogen; sodium hydride; potassium carbonate; triethylamine; N-ethyl-N,N-diisopropylamine; sodium hydroxide; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; palladium on activated charcoal; In tetrahydrofuran; 1,4-dioxane; ethanol; water; isopropyl alcohol; mineral oil;