3-(4-hydroxyphenyl)-3-oxopropanoic acid

Base Information

• Chemical Name: 3-(4-hydroxyphenyl)-3-oxopropanoic acid
• CAS No.: 62024-30-0
• Molecular Formula: C₉H₈O₄
• Molecular Weight: 180.16
• Mol file: 62024-30-0.mol

Synonyms:4-hydroxybenzoylacetic acid

Chemical Property of 3-(4-hydroxyphenyl)-3-oxopropanoic acid

Chemical Property:

• Melting Point: 150 °C(Solv: water (7732-18-5))
• Boiling Point: 464.0±25.0 °C(Predicted)
• PKA: 3.07±0.32(Predicted)
• Density: 1.380±0.06 g/cm3(Predicted)

Purity/Quality:

95% ^*data from raw suppliers

3-(4-hydroxyphenyl)-3-oxopropanoicacid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-(4-hydroxyphenyl)-3-oxopropanoic acid

There total 2 articles about 3-(4-hydroxyphenyl)-3-oxopropanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

3-(4-(benzyloxy)phenyl)-3-oxopropanoic acid (78178-57-1) → 4-hydroxybenzoylacetic acid (62024-30-0)

Guidance literature:

With hydrogen; palladium on activated charcoal; In ethanol;

Reference yield:

ethyl 3-[4-(benzyloxy)phenyl]-3-oxopropanoate (53090-45-2) → 4-hydroxybenzoylacetic acid (62024-30-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 88 percent

2: 93 percent / H₂ / palladium on charcoal / ethanol

With hydrogen; palladium on activated charcoal; In ethanol;

Reference yield: 60.0%

4-hydroxybenzoylacetic acid (62024-30-0) → 4-Hydroxyacetophenone (99-93-4)

Guidance literature:

With sulfuric acid; Heating;

upstream raw materials:

3-(4-(benzyloxy)phenyl)-3-oxopropanoic acid

ethyl 3-[4-(benzyloxy)phenyl]-3-oxopropanoate

Downstream raw materials:

4-Hydroxyacetophenone

Refernces