trans-3-benzyloxycarbonylamino-4-t-butyloxycarbonylmethylcarbamoylmethyl-2-azetidinone

Base Information

Chemical Name:trans-3-benzyloxycarbonylamino-4-t-butyloxycarbonylmethylcarbamoylmethyl-2-azetidinone
CAS No.:142466-77-1
Molecular Formula:C₁₉H₂₅N₃O₆
Molecular Weight:391.424
Hs Code.:

Synonyms:trans-3-benzyloxycarbonylamino-4-t-butyloxycarbonylmethylcarbamoylmethyl-2-azetidinone

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Chemical Property of trans-3-benzyloxycarbonylamino-4-t-butyloxycarbonylmethylcarbamoylmethyl-2-azetidinone

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Technology Process of trans-3-benzyloxycarbonylamino-4-t-butyloxycarbonylmethylcarbamoylmethyl-2-azetidinone

There total 5 articles about trans-3-benzyloxycarbonylamino-4-t-butyloxycarbonylmethylcarbamoylmethyl-2-azetidinone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 6456-74-2
Glycine tert-butyl ester

: 142466-76-0
trans-3-benzyloxycarbonylamino-4-carboxymethyl-2-azetidinone

: 142466-77-1
trans-3-benzyloxycarbonylamino-4-t-butyloxycarbonylmethylcarbamoylmethyl-2-azetidinone

Guidance literature:: With N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline; In dichloromethane; at 20 ℃; for 1.5h;
DOI:10.1016/0223-5234(92)90101-6

Reference yield:

: 75666-47-6
(3S,4S)-3-benzyloxycarbonylamino-4-acetoxy-azetidin-2-one

: 142466-77-1
trans-3-benzyloxycarbonylamino-4-t-butyloxycarbonylmethylcarbamoylmethyl-2-azetidinone

Guidance literature:: Multi-step reaction with 3 steps

1: 81 percent / Zn(OAc)2 / toluene / 2.5 h / 70 °C

2: 53 percent / aq. K₂CO₃ / methanol / 4 h / 20 °C

3: 86 percent / EEDQ / CH₂Cl₂ / 1.5 h / 20 °C

With zinc diacetate; potassium carbonate; N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline; In methanol; dichloromethane; toluene;
DOI:10.1016/0223-5234(92)90101-6

Reference yield:

: 142560-72-3
trans-3-benzyloxycarbonylamino-4-methoxycarbonylmethyl-2-azetidinone

: 142466-77-1
trans-3-benzyloxycarbonylamino-4-t-butyloxycarbonylmethylcarbamoylmethyl-2-azetidinone

Guidance literature:: Multi-step reaction with 2 steps

1: 53 percent / aq. K₂CO₃ / methanol / 4 h / 20 °C

2: 86 percent / EEDQ / CH₂Cl₂ / 1.5 h / 20 °C

With potassium carbonate; N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline; In methanol; dichloromethane;
DOI:10.1016/0223-5234(92)90101-6