4-(3-(4-((5-cyclopropyl-3-(2-(trifluoromethoxy)phenyl)isoxazol-4-yl)methoxy)piperidin-1-yl)-1,2,4-oxadiazol-5-yl)benzoic acid

Base Information

Chemical Name:4-(3-(4-((5-cyclopropyl-3-(2-(trifluoromethoxy)phenyl)isoxazol-4-yl)methoxy)piperidin-1-yl)-1,2,4-oxadiazol-5-yl)benzoic acid
CAS No.:1383743-67-6
Molecular Formula:C₂₈H₂₅F₃N₄O₆
Molecular Weight:570.525
Hs Code.:

Synonyms:4-(3-(4-((5-cyclopropyl-3-(2-(trifluoromethoxy)phenyl)isoxazol-4-yl)methoxy)piperidin-1-yl)-1,2,4-oxadiazol-5-yl)benzoic acid

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Chemical Property of 4-(3-(4-((5-cyclopropyl-3-(2-(trifluoromethoxy)phenyl)isoxazol-4-yl)methoxy)piperidin-1-yl)-1,2,4-oxadiazol-5-yl)benzoic acid

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Technology Process of 4-(3-(4-((5-cyclopropyl-3-(2-(trifluoromethoxy)phenyl)isoxazol-4-yl)methoxy)piperidin-1-yl)-1,2,4-oxadiazol-5-yl)benzoic acid

There total 9 articles about 4-(3-(4-((5-cyclopropyl-3-(2-(trifluoromethoxy)phenyl)isoxazol-4-yl)methoxy)piperidin-1-yl)-1,2,4-oxadiazol-5-yl)benzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1383743-66-5
methyl 4-(3-(4-((5-cyclopropyl-3-(2-(trifluoromethoxy)phenyl)isoxazol-4-yl)methoxy)piperidin-1-yl)-1,2,4-oxadiazol-5-yl)benzoate

: 1383743-67-6
4-(3-(4-((5-cyclopropyl-3-(2-(trifluoromethoxy)phenyl)isoxazol-4-yl)methoxy)piperidin-1-yl)-1,2,4-oxadiazol-5-yl)benzoic acid

Guidance literature:: methyl 4-(3-(4-((5-cyclopropyl-3-(2-(trifluoromethoxy)phenyl)isoxazol-4-yl)methoxy)piperidin-1-yl)-1,2,4-oxadiazol-5-yl)benzoate; With water; lithium hydroxide; In tetrahydrofuran; methanol; at 20 ℃; for 14h;

With hydrogenchloride; In tetrahydrofuran; methanol; water;

Reference yield:

: 1383740-00-8
(E)-2-(trifluoromethoxy)benzaldehyde oxime

: 1383743-67-6
4-(3-(4-((5-cyclopropyl-3-(2-(trifluoromethoxy)phenyl)isoxazol-4-yl)methoxy)piperidin-1-yl)-1,2,4-oxadiazol-5-yl)benzoic acid

Guidance literature:: Multi-step reaction with 11 steps

1.1: N-chloro-succinimide / N,N-dimethyl-formamide / 1 h / 20 - 25 °C

2.1: potassium carbonate / tetrahydrofuran / 0.5 h / -10 °C

2.2: 6 h / -5 - 35 °C

3.1: lithium aluminium tetrahydride / tetrahydrofuran / 0.5 h / -10 °C / Inert atmosphere

4.1: carbon tetrabromide; triphenylphosphine / dichloromethane / 1 h

5.1: potassium tert-butylate; 18-crown-6 ether / tetrahydrofuran / Inert atmosphere

6.1: trifluoroacetic acid / dichloromethane / 1 h

7.1: potassium carbonate / dichloromethane; water / 2 h

8.1: hydroxylamine hydrochloride; sodium acetate / ethanol / 2 h / 60 °C

9.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 3 h / 20 °C

10.1: sodium acetate / ethanol / 2 h / Reflux

11.1: water; lithium hydroxide / tetrahydrofuran; methanol / 14 h / 20 °C

With N-chloro-succinimide; lithium aluminium tetrahydride; 18-crown-6 ether; carbon tetrabromide; hydroxylamine hydrochloride; potassium tert-butylate; water; sodium acetate; potassium carbonate; N-ethyl-N,N-diisopropylamine; triphenylphosphine; HATU; trifluoroacetic acid; lithium hydroxide; In tetrahydrofuran; methanol; ethanol; dichloromethane; water; N,N-dimethyl-formamide;

Reference yield:

: 1383740-02-0
tert-butyl 4-((5-cyclopropyl-3-(2-(trifluoromethoxy)phenyl)isoxazol-4-yl)methoxy)piperidine-1-carboxylate

: 1383743-67-6
4-(3-(4-((5-cyclopropyl-3-(2-(trifluoromethoxy)phenyl)isoxazol-4-yl)methoxy)piperidin-1-yl)-1,2,4-oxadiazol-5-yl)benzoic acid

Guidance literature:: Multi-step reaction with 6 steps

1: trifluoroacetic acid / dichloromethane / 1 h

2: potassium carbonate / dichloromethane; water / 2 h

3: hydroxylamine hydrochloride; sodium acetate / ethanol / 2 h / 60 °C

4: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 3 h / 20 °C

5: sodium acetate / ethanol / 2 h / Reflux

6: water; lithium hydroxide / tetrahydrofuran; methanol / 14 h / 20 °C

With hydroxylamine hydrochloride; water; sodium acetate; potassium carbonate; N-ethyl-N,N-diisopropylamine; HATU; trifluoroacetic acid; lithium hydroxide; In tetrahydrofuran; methanol; ethanol; dichloromethane; water; N,N-dimethyl-formamide;