1-(4-methylenecyclohexyl)-2-[4-(2-methylquinolin-4-ylmethoxy)benzenesulfonyl]ethanone

Base Information

• Chemical Name: 1-(4-methylenecyclohexyl)-2-[4-(2-methylquinolin-4-ylmethoxy)benzenesulfonyl]ethanone
• CAS No.: 502609-80-5
• Molecular Formula: C₂₆H₂₇NO₄S
• Molecular Weight: 449.571
• Mol file: 502609-80-5.mol

Synonyms:1-(4-methylenecyclohexyl)-2-[4-(2-methylquinolin-4-ylmethoxy)benzenesulfonyl]ethanone

Chemical Property of 1-(4-methylenecyclohexyl)-2-[4-(2-methylquinolin-4-ylmethoxy)benzenesulfonyl]ethanone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-(4-methylenecyclohexyl)-2-[4-(2-methylquinolin-4-ylmethoxy)benzenesulfonyl]ethanone

There total 4 articles about 1-(4-methylenecyclohexyl)-2-[4-(2-methylquinolin-4-ylmethoxy)benzenesulfonyl]ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

methyl 4-methylenecyclohexane carboxylate (71092-50-7) → 1-(4-methylenecyclohexyl)-2-[4-(2-methylquinolin-4-ylmethoxy)benzenesulfonyl]ethanone (502609-80-5)

Guidance literature:

4-(2-methylquinolin-4-ylmethoxy)phenylsulphonylmethane; With lithium diisopropyl amide; In tetrahydrofuran; hexane; n-heptane; ethylbenzene; at -78 ℃; for 1h;

methyl 4-methylenecyclohexane carboxylate; In tetrahydrofuran; hexane; n-heptane; ethylbenzene; at -78 ℃; for 4h;

With sulfuric acid; In tetrahydrofuran; hexane; n-heptane; ethylbenzene; water; for 0.166667h;

Reference yield:

4-methanesulfonyl-phenol (14763-60-1) → 1-(4-methylenecyclohexyl)-2-[4-(2-methylquinolin-4-ylmethoxy)benzenesulfonyl]ethanone (502609-80-5)

Guidance literature:

Multi-step reaction with 2 steps

1: aq. NaOH / ethanol

2: lithium diisopropylamide; lithium hexamethyldisilazide

With sodium hydroxide; lithium hexamethyldisilazane; lithium diisopropyl amide; In ethanol;

DOI:10.1016/j.bmcl.2004.03.048

Reference yield:

4-chloromethyl-2-methylquinoline hydrochloride salt → 1-(4-methylenecyclohexyl)-2-[4-(2-methylquinolin-4-ylmethoxy)benzenesulfonyl]ethanone (502609-80-5)

Guidance literature:

Multi-step reaction with 2 steps

1: aq. NaOH / ethanol

2: lithium diisopropylamide; lithium hexamethyldisilazide

With sodium hydroxide; lithium hexamethyldisilazane; lithium diisopropyl amide; In ethanol;

DOI:10.1016/j.bmcl.2004.03.048

upstream raw materials:

4-(2-methylquinolin-4-ylmethoxy)phenylsulphonylmethane

4-methanesulfonyl-phenol

methyl 4-methylenecyclohexane carboxylate

Downstream raw materials:

1-(4-methylenecyclohexyl)-2-[4-(2-methylquinolin-4-ylmethoxy)benzenesulfonyl]ethanol

N-[1-(4-methylenecyclohexyl)-2-{4-(2-methylquinolin-4-ylmethoxy)benzenesulfonyl}ethyl]hydroxylamine