4-(2-((1-(3,4-dichlorophenyl)-5-methyl-1H-pyrazol-3-yl)methoxy)ethyl)morpholine

Base Information

• Chemical Name: 4-(2-((1-(3,4-dichlorophenyl)-5-methyl-1H-pyrazol-3-yl)methoxy)ethyl)morpholine
• CAS No.: 1351437-79-0
• Molecular Formula: C₁₇H₂₁Cl₂N₃O₂
• Molecular Weight: 370.279
• Mol file: 1351437-79-0.mol

Synonyms:4-(2-((1-(3,4-dichlorophenyl)-5-methyl-1H-pyrazol-3-yl)methoxy)ethyl)morpholine

Chemical Property of 4-(2-((1-(3,4-dichlorophenyl)-5-methyl-1H-pyrazol-3-yl)methoxy)ethyl)morpholine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-(2-((1-(3,4-dichlorophenyl)-5-methyl-1H-pyrazol-3-yl)methoxy)ethyl)morpholine

There total 5 articles about 4-(2-((1-(3,4-dichlorophenyl)-5-methyl-1H-pyrazol-3-yl)methoxy)ethyl)morpholine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

(1-(3,4-dichlorophenyl)-5-methyl-1H-pyrazol-3-yl)methanol (1226303-27-0) + 4-(2-iodo-ethyl)-morpholine (126200-24-6) → 4-(2-((1-(3,4-dichlorophenyl)-5-methyl-1H-pyrazol-3-yl)methoxy)ethyl)morpholine (1351437-79-0)

Guidance literature:

(1-(3,4-dichlorophenyl)-5-methyl-1H-pyrazol-3-yl)methanol; With sodium hydride; In tetrahydrofuran; mineral oil; at 20 ℃; for 0.166667h;

4-(2-iodo-ethyl)-morpholine; In tetrahydrofuran; mineral oil; for 2h; Reflux;

Reference yield:

3,4-dichlorophenylhydrazine hydrochloride (19763-90-7) → 4-(2-((1-(3,4-dichlorophenyl)-5-methyl-1H-pyrazol-3-yl)methoxy)ethyl)morpholine (1351437-79-0)

Guidance literature:

Multi-step reaction with 3 steps

1.1: acetic acid / 1 h / Reflux

2.1: sodium tetrahydroborate / ethanol / 5 h / Reflux

3.1: sodium hydride / tetrahydrofuran; mineral oil / 0.17 h / 20 °C

3.2: 2 h / Reflux

With sodium tetrahydroborate; sodium hydride; acetic acid; In tetrahydrofuran; ethanol; mineral oil;

Reference yield:

ethyl 1-(3,4-dichlorophenyl)-5-methyl-1H-pyrazole-3-carboxylate (1020724-07-5) → 4-(2-((1-(3,4-dichlorophenyl)-5-methyl-1H-pyrazol-3-yl)methoxy)ethyl)morpholine (1351437-79-0)

Guidance literature:

Multi-step reaction with 2 steps

1.1: sodium tetrahydroborate / ethanol / 5 h / Reflux

2.1: sodium hydride / tetrahydrofuran; mineral oil / 0.17 h / 20 °C

2.2: 2 h / Reflux

With sodium tetrahydroborate; sodium hydride; In tetrahydrofuran; ethanol; mineral oil;

upstream raw materials:

3,4-dichlorophenylhydrazine hydrochloride

N-(2-chlorethyl)morpholine

(1-(3,4-dichlorophenyl)-5-methyl-1H-pyrazol-3-yl)methanol

4-(2-iodo-ethyl)-morpholine