1-(2-Naphthalenylmethyl)-3-piperidinamine

Base Information

• Chemical Name: 1-(2-Naphthalenylmethyl)-3-piperidinamine
• CAS No.: 1027513-67-2
• Molecular Formula: C₁₆H₂₀N₂
• Molecular Weight: 240.348
• DSSTox Substance ID: DTXSID801273048
• Mol file: 1027513-67-2.mol

Synonyms:1-(2-Naphthalenylmethyl)-3-piperidinamine;DTXSID801273048;AKOS010549472;1027513-67-2

Chemical Property of 1-(2-Naphthalenylmethyl)-3-piperidinamine

Chemical Property:

• XLogP3: 2.6
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 240.162648646
• Heavy Atom Count: 18
• Complexity: 266

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: C1CC(CN(C1)CC2=CC3=CC=CC=C3C=C2)N

Technology Process of 1-(2-Naphthalenylmethyl)-3-piperidinamine

There total 1 articles about 1-(2-Naphthalenylmethyl)-3-piperidinamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

t-butyl piperidin-3-ylcarbamate (184637-48-7,172603-05-3) → 1-naphthalen-2-ylmethyl-piperidin-3-ylamine (1027513-67-2)

Guidance literature:

Multi-step reaction with 2 steps

1: TEA / CH₂Cl₂

2: TFA / CH₂Cl₂

With TEA; trifluoroacetic acid; In dichloromethane;

DOI:10.1016/j.bmcl.2006.07.053

Reference yield:

1-naphthalen-2-ylmethyl-piperidin-3-ylamine (1027513-67-2) + 3,5-dimethoxybenzoic acid (1132-21-4) → 3,5-dimethoxy-N-(1-naphthalen-2-ylmethyl-piperidin-3-yl)-benzamide

Guidance literature:

With 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran;

DOI:10.1016/j.bmcl.2006.07.053

upstream raw materials:

t-butyl piperidin-3-ylcarbamate