(+)-(1R,2R)-3-[2-(dimethylamino)-methyl-1-hydroxycyclohexyl]phenol octanoate

Base Information

Chemical Name:(+)-(1R,2R)-3-[2-(dimethylamino)-methyl-1-hydroxycyclohexyl]phenol octanoate
CAS No.:1334208-76-2
Molecular Formula:C₈H₁₆O₂*C₁₅H₂₃NO₂
Molecular Weight:393.567
Hs Code.:

Synonyms:(+)-(1R,2R)-3-[2-(dimethylamino)-methyl-1-hydroxycyclohexyl]phenol octanoate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (+)-(1R,2R)-3-[2-(dimethylamino)-methyl-1-hydroxycyclohexyl]phenol octanoate

Chemical Property:

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Technology Process of (+)-(1R,2R)-3-[2-(dimethylamino)-methyl-1-hydroxycyclohexyl]phenol octanoate

There total 2 articles about (+)-(1R,2R)-3-[2-(dimethylamino)-methyl-1-hydroxycyclohexyl]phenol octanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.3%

: 124-07-2
Octanoic acid

: 144830-14-8
(+)-O-Demethyltramadol

: 1334208-76-2
(+)-(1R,2R)-3-[2-(dimethylamino)-methyl-1-hydroxycyclohexyl]phenol octanoate

Guidance literature:: In tert-butyl methyl ether; at 23 ℃; for 22h; Product distribution / selectivity;

Reference yield:

: 148262-77-5,185453-02-5
(+)-O-Demethyltramadol hydrochloride

: 1334208-76-2
(+)-(1R,2R)-3-[2-(dimethylamino)-methyl-1-hydroxycyclohexyl]phenol octanoate

Guidance literature:: Multi-step reaction with 2 steps

1: sodium hydroxide / water / 0.65 h / 22 °C / pH 6 - 9.93

2: tert-butyl methyl ether / 22 h / 23 °C

With sodium hydroxide; In tert-butyl methyl ether; water;