N,N-dibenzyl-O-tert-butyl-L-tyrosylglycylglycyl-L-p-amino(9-fluorenylmethoxycarbonyl)phenylalanyl-L-leucine tert-butyl ester

Base Information

Chemical Name:N,N-dibenzyl-O-tert-butyl-L-tyrosylglycylglycyl-L-p-amino(9-fluorenylmethoxycarbonyl)phenylalanyl-L-leucine tert-butyl ester
CAS No.:309729-36-0
Molecular Formula:C₆₅H₇₆N₆O₉
Molecular Weight:1085.35
Hs Code.:

Synonyms:N,N-dibenzyl-O-tert-butyl-L-tyrosylglycylglycyl-L-p-amino(9-fluorenylmethoxycarbonyl)phenylalanyl-L-leucine tert-butyl ester

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Chemical Property of N,N-dibenzyl-O-tert-butyl-L-tyrosylglycylglycyl-L-p-amino(9-fluorenylmethoxycarbonyl)phenylalanyl-L-leucine tert-butyl ester

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Technology Process of N,N-dibenzyl-O-tert-butyl-L-tyrosylglycylglycyl-L-p-amino(9-fluorenylmethoxycarbonyl)phenylalanyl-L-leucine tert-butyl ester

There total 3 articles about N,N-dibenzyl-O-tert-butyl-L-tyrosylglycylglycyl-L-p-amino(9-fluorenylmethoxycarbonyl)phenylalanyl-L-leucine tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₃₆H₄₅N₃O₇

: L-p-amino(9-fluorenylmethyloxycarbonyl)phenylalanyl-L-leucine tert-butyl ester triflate salt

: 309729-36-0
N,N-dibenzyl-O-tert-butyl-L-tyrosylglycylglycyl-L-p-amino(9-fluorenylmethoxycarbonyl)phenylalanyl-L-leucine tert-butyl ester

Guidance literature:: With 4-methyl-morpholine; In tetrahydrofuran; N,N-dimethyl-formamide; at -15 - 20 ℃;
DOI:10.1021/jm000123u

Reference yield:

: 109363-33-9
N,N-dibenzyl-O-tert-butyl-L-tyrosylglycylglycine

: 309729-36-0
N,N-dibenzyl-O-tert-butyl-L-tyrosylglycylglycyl-L-p-amino(9-fluorenylmethoxycarbonyl)phenylalanyl-L-leucine tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: N-methylmorpholine / dimethylformamide / 0.03 h / -15 °C

2: N-methylmorpholine / dimethylformamide; tetrahydrofuran / -15 - 20 °C

With 4-methyl-morpholine; In tetrahydrofuran; N,N-dimethyl-formamide; 1: Acylation / 2: Condensation;
DOI:10.1021/jm000123u

Reference yield:

: 309729-33-7
N^α-tert-butyloxycarbonyl-L-p-amino(9-fluorenylmethyloxycarbonyl)phenylalanyl-L-leucine tert-butyl ester

: 309729-36-0
N,N-dibenzyl-O-tert-butyl-L-tyrosylglycylglycyl-L-p-amino(9-fluorenylmethoxycarbonyl)phenylalanyl-L-leucine tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 97 percent / toluene; CH₂Cl₂ / 4 h

2: N-methylmorpholine / dimethylformamide; tetrahydrofuran / -15 - 20 °C

With 4-methyl-morpholine; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; toluene; 1: deacylation / 2: Condensation;
DOI:10.1021/jm000123u