3,5-Bis-[2-(4-{2-[3-methyl-5-(2-triisopropylsilylethynyl)phenyl]ethynyl}-5-propyloxy-2-(tetrahydro-2H-pyran-2-yloxy)phenyl)ethynyl]toluene

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Chemical Name:3,5-Bis-[2-(4-{2-[3-methyl-5-(2-triisopropylsilylethynyl)phenyl]ethynyl}-5-propyloxy-2-(tetrahydro-2H-pyran-2-yloxy)phenyl)ethynyl]toluene
CAS No.:220117-63-5
Molecular Formula:C₇₉H₉₆O₆Si₂
Molecular Weight:1197.8
Hs Code.:

Synonyms:3,5-Bis-[2-(4-{2-[3-methyl-5-(2-triisopropylsilylethynyl)phenyl]ethynyl}-5-propyloxy-2-(tetrahydro-2H-pyran-2-yloxy)phenyl)ethynyl]toluene

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Chemical Property of 3,5-Bis-[2-(4-{2-[3-methyl-5-(2-triisopropylsilylethynyl)phenyl]ethynyl}-5-propyloxy-2-(tetrahydro-2H-pyran-2-yloxy)phenyl)ethynyl]toluene

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Technology Process of 3,5-Bis-[2-(4-{2-[3-methyl-5-(2-triisopropylsilylethynyl)phenyl]ethynyl}-5-propyloxy-2-(tetrahydro-2H-pyran-2-yloxy)phenyl)ethynyl]toluene

There total 10 articles about 3,5-Bis-[2-(4-{2-[3-methyl-5-(2-triisopropylsilylethynyl)phenyl]ethynyl}-5-propyloxy-2-(tetrahydro-2H-pyran-2-yloxy)phenyl)ethynyl]toluene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 49617-79-0
1,3-diiodo-5-methylbenzene

: 220117-62-4
{3-[4-Ethynyl-2-propoxy-5-(tetrahydro-pyran-2-yloxy)-phenylethynyl]-5-methyl-phenylethynyl}-triisopropyl-silane

: 220117-63-5
3,5-Bis-[2-(4-{2-[3-methyl-5-(2-triisopropylsilylethynyl)phenyl]ethynyl}-5-propyloxy-2-(tetrahydro-2H-pyran-2-yloxy)phenyl)ethynyl]toluene

Guidance literature:: With piperidine; triphenylphosphine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; 1.) r.t., 1 h, 2.) 35 deg C, overnight;
DOI:10.1002/(SICI)1521-3765(19981204)4:12<2423::AID-CHEM2423>3.0.CO;2-8

Reference yield:

: 110-87-2
3,4-dihydro-2H-pyran

: 220117-63-5
3,5-Bis-[2-(4-{2-[3-methyl-5-(2-triisopropylsilylethynyl)phenyl]ethynyl}-5-propyloxy-2-(tetrahydro-2H-pyran-2-yloxy)phenyl)ethynyl]toluene

Guidance literature:: Multi-step reaction with 5 steps

1: 82 percent / p-TsOH / CH₂Cl₂ / 1.) 0 deg C, 1 h, 2.) r.t., 1 h

2: PPh₃, piperidine / Pd(PPh₃)2Cl₂, CuI / 1.) r.t., 2 d, 2.) 55 deg C, 2 d

3: PPh₃, piperidine / Pd(PPh₃)2Cl₂, CuI / 96 h / 55 °C

4: 93 percent / K₂CO₃ / methanol; tetrahydrofuran

5: 92 percent / PPh₃, piperidine / Pd(PPh₃)2Cl₂, CuI / 1.) r.t., 1 h, 2.) 35 deg C, overnight

With piperidine; potassium carbonate; toluene-4-sulfonic acid; triphenylphosphine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1002/(SICI)1521-3765(19981204)4:12<2423::AID-CHEM2423>3.0.CO;2-8

Reference yield:

: 116632-38-3
1-bromo-3-iodo-5-methylbenzene

: 220117-63-5
3,5-Bis-[2-(4-{2-[3-methyl-5-(2-triisopropylsilylethynyl)phenyl]ethynyl}-5-propyloxy-2-(tetrahydro-2H-pyran-2-yloxy)phenyl)ethynyl]toluene

Guidance literature:: Multi-step reaction with 6 steps

1: 1.) PPh₃, piperidine / 1.) PdCl₂(PPh₃)2, CuI / 1.) r.t., 2 d; 55 deg C, 2 d, 2.) 55 deg C, 4 d

2: 95 percent / K₂CO₃ / methanol; tetrahydrofuran

3: PPh₃, piperidine / Pd(PPh₃)2Cl₂, CuI / 1.) r.t., 2 d, 2.) 55 deg C, 2 d

4: PPh₃, piperidine / Pd(PPh₃)2Cl₂, CuI / 96 h / 55 °C

5: 93 percent / K₂CO₃ / methanol; tetrahydrofuran

6: 92 percent / PPh₃, piperidine / Pd(PPh₃)2Cl₂, CuI / 1.) r.t., 1 h, 2.) 35 deg C, overnight

With piperidine; potassium carbonate; triphenylphosphine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; In tetrahydrofuran; methanol;
DOI:10.1002/(SICI)1521-3765(19981204)4:12<2423::AID-CHEM2423>3.0.CO;2-8