2,6-Dichloro-3-fluoropyridine

Base Information

• Chemical Name: 2,6-Dichloro-3-fluoropyridine
• CAS No.: 52208-50-1
• Molecular Formula: C5H2Cl2FN
• Molecular Weight: 165.982
• Hs Code.: 2933399090
• DSSTox Substance ID: DTXSID70535016
• Wikidata: Q72466315
• Mol file: 52208-50-1.mol

Synonyms:2,6-Dichloro-3-fluoropyridine;52208-50-1;Pyridine, 2,6-dichloro-3-fluoro-;2,6-dichloro-3-fluoro-pyridine;MFCD09907815;2,6-dichloro-5-fluoropyridine;SCHEMBL411439;DTXSID70535016;YAXSIJLRAOURJK-UHFFFAOYSA-N;AMY28491;BCP29988;AKOS006311785;CS-W003683;SB21300;2 pound not6-Dichloro-3-fluoropyridine;AC-24925;AS-18395;SY020345;A7669;EN300-317197;J-507417

Chemical Property of 2,6-Dichloro-3-fluoropyridine

Chemical Property:

• Appearance/Colour: White solid
• Vapor Pressure: 0.571mmHg at 25°C
• Melting Point: 44-46 °C
• Refractive Index: 1.528
• Boiling Point: 196.034 °C at 760 mmHg
• PKA: -3.21±0.10(Predicted)
• Flash Point: 72.359 °C
• PSA: 12.89000
• Density: 1.498g/cm3
• LogP: 2.52750
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• XLogP3: 2.2
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 0
• Exact Mass: 164.9548326
• Heavy Atom Count: 9
• Complexity: 101

Purity/Quality:

99% ^*data from raw suppliers

2,6-Dichloro-3-fluoropyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC(=NC(=C1F)Cl)Cl

Technology Process of 2,6-Dichloro-3-fluoropyridine

There total 4 articles about 2,6-Dichloro-3-fluoropyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

2,6-dichloro-3-pyridinediazonium tetrafluoroborate → 2,6-dichloro-3-fluoropyridine (52208-50-1)

Guidance literature:

With magnesium sulfate; at 170 - 200 ℃; under 4 - 10 Torr;

DOI:10.1002/jhet.5570210309

Reference yield:

3-amino-2,6-dichloropyridine (62476-56-6) → 2,6-dichloro-3-fluoropyridine (52208-50-1)

Guidance literature:

With tetrafluoroboric acid; Heating;

Reference yield:

2,6-dicholoro-3-nitropyridine (16013-85-7,136901-10-5) → 2,6-dichloro-3-fluoropyridine (52208-50-1)

Guidance literature:

Multi-step reaction with 2 steps

1: SnCl₂ / pH <7

2: HBF₄ / Heating

With tetrafluoroboric acid; tin(ll) chloride;

upstream raw materials:

3-amino-2,6-dichloropyridine

2,6-dicholoro-3-nitropyridine

Downstream raw materials:

6-chloro-2-(4-chloro-phenyl)-3-(2,2,2-trifluoro-ethoxy)-pyridine

2-(4-chloro-phenyl)-3-fluoro-6-(2,2,2-trifluoro-ethoxy)-pyridine