Technology Process of 3-benzyloxycarbonyl-7-benzyloxymethyl-1,2,3,4,5,6,7,8,9,10-decahydroazacycloundecino<5,4-b>indol-9-carbonsaeure
There total 9 articles about 3-benzyloxycarbonyl-7-benzyloxymethyl-1,2,3,4,5,6,7,8,9,10-decahydroazacycloundecino<5,4-b>indol-9-carbonsaeure which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
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107688-28-8,116260-69-6,116260-75-4
3-benzyloxycarbonyl-7-benzyloxymethyl-1,2,3,4,5,6,7,8,9,10-decahydroazacycloundecino<5,4-b>indol-9-carbonsauremethylester
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116171-86-9
3-benzyloxycarbonyl-7-benzyloxymethyl-1,2,3,4,5,6,7,8,9,10-decahydroazacycloundecino<5,4-b>indol-9-carbonsaeure
- Guidance literature:
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With
hydrogenchloride; sodium hydroxide; water; ethyl acetate;
In
ethanol;
at 100 ℃;
for 100h;
Yield given;
DOI:10.1016/S0040-4020(01)86863-0
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116171-86-9
3-benzyloxycarbonyl-7-benzyloxymethyl-1,2,3,4,5,6,7,8,9,10-decahydroazacycloundecino<5,4-b>indol-9-carbonsaeure
- Guidance literature:
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Multi-step reaction with 6 steps
1: anhydrous sodium carbonate / tetrahydrofuran / 16 h / 50 °C
2: 98 percent / pyridine / 1 h / 40 °C
3: 98 percent / tetra-n-butyl ammonium bromide, sodium iodide / toluene / 2 h / Heating
4: 90 percent / sodium hydroxide, 30percent hydrogen peroxide / ethanol / 3 h / Ambient temperature
5: 77 percent / Amberlyst 15 / 120 h / 60 °C
6: sodium hydroxide, water, ethyl acetate, HCl / ethanol / 100 h / 100 °C
With
pyridine; hydrogenchloride; sodium hydroxide; Amberlyst 15; tetrabutylammomium bromide; water; dihydrogen peroxide; sodium carbonate; ethyl acetate; sodium iodide;
In
tetrahydrofuran; ethanol; toluene;
DOI:10.1016/S0040-4020(01)86863-0
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107688-23-3
2-benzyloxymethyl-2,3,4,5,6,7,8,13,13b-octahydro-1H-azepino<1',2':1,2>pyrido<3,4-b>indol
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116171-86-9
3-benzyloxycarbonyl-7-benzyloxymethyl-1,2,3,4,5,6,7,8,9,10-decahydroazacycloundecino<5,4-b>indol-9-carbonsaeure
- Guidance literature:
-
Multi-step reaction with 6 steps
1: anhydrous sodium carbonate / tetrahydrofuran / 16 h / 50 °C
2: 98 percent / pyridine / 1 h / 40 °C
3: 98 percent / tetra-n-butyl ammonium bromide, sodium iodide / toluene / 2 h / Heating
4: 90 percent / sodium hydroxide, 30percent hydrogen peroxide / ethanol / 3 h / Ambient temperature
5: 77 percent / Amberlyst 15 / 120 h / 60 °C
6: sodium hydroxide, water, ethyl acetate, HCl / ethanol / 100 h / 100 °C
With
pyridine; hydrogenchloride; sodium hydroxide; Amberlyst 15; tetrabutylammomium bromide; water; dihydrogen peroxide; sodium carbonate; ethyl acetate; sodium iodide;
In
tetrahydrofuran; ethanol; toluene;
DOI:10.1016/S0040-4020(01)86863-0
