1-Amino-3-(benzyloxycarbonylamino-methyl)-cyclobutanecarboxylic acid

Base Information

Chemical Name:1-Amino-3-(benzyloxycarbonylamino-methyl)-cyclobutanecarboxylic acid
CAS No.:184103-71-7
Molecular Formula:C₁₄H₁₈N₂O₄
Molecular Weight:278.308
Hs Code.:

Synonyms:1-Amino-3-(benzyloxycarbonylamino-methyl)-cyclobutanecarboxylic acid

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Chemical Property of 1-Amino-3-(benzyloxycarbonylamino-methyl)-cyclobutanecarboxylic acid

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Technology Process of 1-Amino-3-(benzyloxycarbonylamino-methyl)-cyclobutanecarboxylic acid

There total 4 articles about 1-Amino-3-(benzyloxycarbonylamino-methyl)-cyclobutanecarboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 161181-57-3
trans-1-(benzoylamino)-3-(hydroxymethyl)cyclobutane-1-N,N-pentamethylenecarboxamide

: 184103-71-7
1-Amino-3-(benzyloxycarbonylamino-methyl)-cyclobutanecarboxylic acid

Guidance literature:: Multi-step reaction with 5 steps

1: 70 percent / Et₃N / CH₂Cl₂ / 1 h / Ambient temperature

2: 70 percent / N,N,N',N'-tetramethylguanidinium azide / various solvent(s) / 2 h / 80 °C

3: H₂ / 10percent Pd/C / ethanol / 20 h / 760 Torr / Ambient temperature

4: 97 percent / 6N aq. HCl / 20 h / 130 °C

5: 1.) aq. basic CuCO₃, 2.) MgO, 3.) 0.9 N aq. HCl, Na₂S

With hydrogenchloride; sodium sulfide; copper (II) carbonate hydroxide; N,N,N',N'-tetramethylguanidinium azide; hydrogen; magnesium oxide; triethylamine; palladium on activated charcoal; In ethanol; dichloromethane;
DOI:10.1021/jm960390t

Reference yield:

: 166667-10-3
trans-1-(benzoylamino)-3-<<(methylsulfonyl)oxy>methyl>cyclobutane-N,N-pentamethylenecarboxamide

: 184103-71-7
1-Amino-3-(benzyloxycarbonylamino-methyl)-cyclobutanecarboxylic acid

Guidance literature:: Multi-step reaction with 4 steps

1: 70 percent / N,N,N',N'-tetramethylguanidinium azide / various solvent(s) / 2 h / 80 °C

2: H₂ / 10percent Pd/C / ethanol / 20 h / 760 Torr / Ambient temperature

3: 97 percent / 6N aq. HCl / 20 h / 130 °C

4: 1.) aq. basic CuCO₃, 2.) MgO, 3.) 0.9 N aq. HCl, Na₂S

With hydrogenchloride; sodium sulfide; copper (II) carbonate hydroxide; N,N,N',N'-tetramethylguanidinium azide; hydrogen; magnesium oxide; palladium on activated charcoal; In ethanol;
DOI:10.1021/jm960390t

Reference yield:

: 184103-23-9
N-[3-Azidomethyl-1-(piperidine-1-carbonyl)-cyclobutyl]-benzamide

: 184103-71-7
1-Amino-3-(benzyloxycarbonylamino-methyl)-cyclobutanecarboxylic acid

Guidance literature:: Multi-step reaction with 3 steps

1: H₂ / 10percent Pd/C / ethanol / 20 h / 760 Torr / Ambient temperature

2: 97 percent / 6N aq. HCl / 20 h / 130 °C

3: 1.) aq. basic CuCO₃, 2.) MgO, 3.) 0.9 N aq. HCl, Na₂S

With hydrogenchloride; sodium sulfide; copper (II) carbonate hydroxide; hydrogen; magnesium oxide; palladium on activated charcoal; In ethanol;
DOI:10.1021/jm960390t