9-((6-((cis-4-methylcyclohexyl)amino)-5-(trifluoromethyl)naphthalen-2-yl)methyl)-9-azabicyclo[3.3.1]nonane-3-carboxylic acid

Base Information

Chemical Name:9-((6-((cis-4-methylcyclohexyl)amino)-5-(trifluoromethyl)naphthalen-2-yl)methyl)-9-azabicyclo[3.3.1]nonane-3-carboxylic acid
CAS No.:1549947-94-5
Molecular Formula:C₂₈H₃₅F₃N₂O₂
Molecular Weight:488.593
Hs Code.:

Synonyms:9-((6-((cis-4-methylcyclohexyl)amino)-5-(trifluoromethyl)naphthalen-2-yl)methyl)-9-azabicyclo[3.3.1]nonane-3-carboxylic acid

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Chemical Property of 9-((6-((cis-4-methylcyclohexyl)amino)-5-(trifluoromethyl)naphthalen-2-yl)methyl)-9-azabicyclo[3.3.1]nonane-3-carboxylic acid

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Technology Process of 9-((6-((cis-4-methylcyclohexyl)amino)-5-(trifluoromethyl)naphthalen-2-yl)methyl)-9-azabicyclo[3.3.1]nonane-3-carboxylic acid

There total 6 articles about 9-((6-((cis-4-methylcyclohexyl)amino)-5-(trifluoromethyl)naphthalen-2-yl)methyl)-9-azabicyclo[3.3.1]nonane-3-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

: 1427386-78-4
9-aza-bicyclo[3.3.1]nonane-3-carboxylic acid methyl ester hydrochloride

: 1544664-23-4
6-((cis-4-methylcyclohexyl)amino)-5-(trifluoromethyl)-2-naphthaldehyde

: 1549947-94-5
9-((6-((cis-4-methylcyclohexyl)amino)-5-(trifluoromethyl)naphthalen-2-yl)methyl)-9-azabicyclo[3.3.1]nonane-3-carboxylic acid

Guidance literature:: 9-aza-bicyclo[3.3.1]nonane-3-carboxylic acid methyl ester hydrochloride; With triethylamine; In tetrahydrofuran; at 20 ℃; for 0.25h;

6-((cis-4-methylcyclohexyl)amino)-5-(trifluoromethyl)-2-naphthaldehyde; With sodium tris(acetoxy)borohydride; acetic acid; In tetrahydrofuran; at 100 ℃; for 0.333333h; Micellar solution;

With water; sodium hydroxide; In tetrahydrofuran; methanol; at 100 ℃; for 0.166667h; Microwave irradiation;

Reference yield:

: 1544664-16-5
methyl 6-((cis-4-(methyl)cyclohexyl)amino)-2-naphthoate

: 1549947-94-5
9-((6-((cis-4-methylcyclohexyl)amino)-5-(trifluoromethyl)naphthalen-2-yl)methyl)-9-azabicyclo[3.3.1]nonane-3-carboxylic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: lithium aluminium tetrahydride / tetrahydrofuran / 2 h / 0 °C

2.1: manganese(IV) oxide / dichloromethane / 16 h / 20 °C

3.1: dichloromethane / 16 h / 80 °C

4.1: triethylamine / tetrahydrofuran / 0.25 h / 20 °C

4.2: 0.33 h / 100 °C / Micellar solution

4.3: 0.17 h / 100 °C / Microwave irradiation

With manganese(IV) oxide; lithium aluminium tetrahydride; triethylamine; In tetrahydrofuran; dichloromethane;

Reference yield:

: 589-92-4
1-methylcyclohexan-4-one

: 1549947-94-5
9-((6-((cis-4-methylcyclohexyl)amino)-5-(trifluoromethyl)naphthalen-2-yl)methyl)-9-azabicyclo[3.3.1]nonane-3-carboxylic acid

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium tris(acetoxy)borohydride; acetic acid / 1,2-dichloro-ethane / 16 h / 80 °C

2.1: lithium aluminium tetrahydride / tetrahydrofuran / 2 h / 0 °C

3.1: manganese(IV) oxide / dichloromethane / 16 h / 20 °C

4.1: dichloromethane / 16 h / 80 °C

5.1: triethylamine / tetrahydrofuran / 0.25 h / 20 °C

5.2: 0.33 h / 100 °C / Micellar solution

5.3: 0.17 h / 100 °C / Microwave irradiation

With manganese(IV) oxide; lithium aluminium tetrahydride; sodium tris(acetoxy)borohydride; acetic acid; triethylamine; In tetrahydrofuran; dichloromethane; 1,2-dichloro-ethane;