N-{4-[4-bromo-1-(tetrahydro-2-furanylmethyl)-1H-pyrazol-3-yl]phenyl}-N'-phenylurea

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Chemical Name:N-{4-[4-bromo-1-(tetrahydro-2-furanylmethyl)-1H-pyrazol-3-yl]phenyl}-N'-phenylurea
CAS No.:942919-23-5
Molecular Formula:C₂₁H₂₁BrN₄O₂
Molecular Weight:441.327
Hs Code.:

Synonyms:N-{4-[4-bromo-1-(tetrahydro-2-furanylmethyl)-1H-pyrazol-3-yl]phenyl}-N'-phenylurea

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Chemical Property of N-{4-[4-bromo-1-(tetrahydro-2-furanylmethyl)-1H-pyrazol-3-yl]phenyl}-N'-phenylurea

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Technology Process of N-{4-[4-bromo-1-(tetrahydro-2-furanylmethyl)-1H-pyrazol-3-yl]phenyl}-N'-phenylurea

There total 2 articles about N-{4-[4-bromo-1-(tetrahydro-2-furanylmethyl)-1H-pyrazol-3-yl]phenyl}-N'-phenylurea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

: 1192-30-9
tetrahydrofurfuryl bromide

: 942919-23-5
N-{4-[4-bromo-1-(tetrahydro-2-furanylmethyl)-1H-pyrazol-3-yl]phenyl}-N'-phenylurea

Guidance literature:: N-[4-(4-bromo-1H-pyrazol-3-yl)phenyl]-N'-phenylurea; With potassium tert-butylate; In tetrahydrofuran; N,N-dimethyl-formamide; at 0 ℃; for 0.25h;

tetrahydrofurfuryl bromide; In tetrahydrofuran; N,N-dimethyl-formamide; at 20 ℃; for 18h;

Reference yield: 53.0%

: 1192-30-9
tetrahydrofurfuryl bromide

: 942920-31-2
N-[4-(4-bromo-1H-pyrazol-3-yl)phenyl]-N'-phenylurea

: 942919-23-5
N-{4-[4-bromo-1-(tetrahydro-2-furanylmethyl)-1H-pyrazol-3-yl]phenyl}-N'-phenylurea

Guidance literature:: N-[4-(4-bromo-1H-pyrazol-3-yl)phenyl]-N'-phenylurea; With potassium tert-butylate; In tetrahydrofuran; N,N-dimethyl-formamide; at 0 ℃; for 0.25h;

tetrahydrofurfuryl bromide; In tetrahydrofuran; N,N-dimethyl-formamide; at 0 - 20 ℃;
DOI:10.1021/jm901870q

Reference yield: 11.0%

: 942919-24-6
1-(phenylsulfonyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrrolo-[2,3-b]pyridine

: 942919-23-5
N-{4-[4-bromo-1-(tetrahydro-2-furanylmethyl)-1H-pyrazol-3-yl]phenyl}-N'-phenylurea

: 942917-43-3
N-phenyl-N'-{4-[4-(1H-pyrrolo[2,3-b]pyridin-4-yl)-1-(tetrahydro-2-furanylmethyl)-1H-pyrazol-3-yl]phenyl}urea

Guidance literature:: 1-(phenylsulfonyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrrolo-[2,3-b]pyridine; N-{4-[4-bromo-1-(tetrahydro-2-furanylmethyl)-1H-pyrazol-3-yl]phenyl}-N'-phenylurea; With potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In N,N-dimethyl-formamide; at 100 ℃; for 18h;

With methanol; sodium hydroxide; water; at 70 ℃; for 6h;