1-<(methoxycarbonyl)methyl>-3-(4-nitrobenzyloxy)-2(1H)pyridinone

Base Information

• Chemical Name: 1-<(methoxycarbonyl)methyl>-3-(4-nitrobenzyloxy)-2(1H)pyridinone
• CAS No.: 222317-04-6
• Molecular Formula: C₁₅H₁₄N₂O₆
• Molecular Weight: 318.286
• Mol file: 222317-04-6.mol

Synonyms:1-<(methoxycarbonyl)methyl>-3-(4-nitrobenzyloxy)-2(1H)pyridinone

Chemical Property of 1-<(methoxycarbonyl)methyl>-3-(4-nitrobenzyloxy)-2(1H)pyridinone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-<(methoxycarbonyl)methyl>-3-(4-nitrobenzyloxy)-2(1H)pyridinone

There total 2 articles about 1-<(methoxycarbonyl)methyl>-3-(4-nitrobenzyloxy)-2(1H)pyridinone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

1-bromomethyl-4-nitro-benzene (100-11-8) + 1-<(methoxycarbonyl)methyl>-3-hydroxy-2(1H)pyridinone (95215-71-7) → 1-<(methoxycarbonyl)methyl>-3-(4-nitrobenzyloxy)-2(1H)pyridinone (222317-04-6)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 50 - 60 ℃; for 18h;

DOI:10.1016/S0040-4020(98)01091-6

Reference yield:

1-ethoxycarbonylmethyl-3-hydroxy pyrid-2-one (95215-70-6) → 1-<(methoxycarbonyl)methyl>-3-(4-nitrobenzyloxy)-2(1H)pyridinone (222317-04-6)

Guidance literature:

Multi-step reaction with 3 steps

1: 84 percent / hydrochloric acid / 12 h / Heating; pH 1

2: 83 percent / hydrogen chloride / 3 h / Heating

3: 58 percent / potassium carbonate / dimethylformamide / 18 h / 50 - 60 °C

With hydrogenchloride; potassium carbonate; In N,N-dimethyl-formamide;

DOI:10.1016/S0040-4020(98)01091-6

Reference yield: 90.0%

1-<(methoxycarbonyl)methyl>-3-(4-nitrobenzyloxy)-2(1H)pyridinone (222317-04-6) → 1-carboxymethyl-3-(4-nitrobenzyloxy)-2(1H)pyridinone (222317-05-7)

Guidance literature:

With sodium hydroxide; In methanol; water; for 3h; Ambient temperature;

DOI:10.1016/S0040-4020(98)01091-6

upstream raw materials:

1-bromomethyl-4-nitro-benzene

1-<(methoxycarbonyl)methyl>-3-hydroxy-2(1H)pyridinone

1-ethoxycarbonylmethyl-3-hydroxy pyrid-2-one

Downstream raw materials:

1-carboxymethyl-3-(4-nitrobenzyloxy)-2(1H)pyridinone

2-[3-(4-nitro-benzyloxy)-2-oxo-2H-pyridin-1-yl]-N-propyl-acetamide