C₁₇H₁₇⁽²⁾HN₂O

Base Information

• Chemical Name: C₁₇H₁₇⁽²⁾HN₂O
• CAS No.: 1309672-32-9
• Molecular Formula: C₁₇H₁₈N₂O
• Molecular Weight: 267.335
• Mol file: 1309672-32-9.mol

Synonyms:C₁₇H₁₇⁽²⁾HN₂O

Chemical Property of C₁₇H₁₇⁽²⁾HN₂O

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₁₇H₁₇⁽²⁾HN₂O

There total 4 articles about C₁₇H₁₇⁽²⁾HN₂O which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

(Z)-N-benzylprop-2-en-3-d-1-amine (1026909-50-1) + phenyl isocyanate (103-71-9) → C17H17(2)HN2O (1309672-32-9)

Guidance literature:

With triethylamine; In dichloromethane; at 0 - 20 ℃; for 1h; Inert atmosphere;

DOI:10.1002/anie.201100293

Reference yield:

N-(tert-butoxycarbonyl)-N-benzyl-3-amino-1-propyne → C17H17(2)HN2O (1309672-32-9)

Guidance literature:

Multi-step reaction with 4 steps

1.1: n-butyllithium / tetrahydrofuran / 1 h / -78 - 0 °C

1.2: -78 °C

2.1: Schwartz's reagent; diisobutylaluminium hydride / tetrahydrofuran; toluene / 1 h / 20 °C / Inert atmosphere

2.2: 1 h / Inert atmosphere

3.1: trifluoroacetic acid / dichloromethane / 1 h / 20 °C

4.1: triethylamine / dichloromethane / 1 h / 0 - 20 °C / Inert atmosphere

With Schwartz's reagent; n-butyllithium; diisobutylaluminium hydride; triethylamine; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; toluene;

DOI:10.1002/anie.201100293

Reference yield:

C15H20(2)HNO2 (1309672-31-8) → C17H17(2)HN2O (1309672-32-9)

Guidance literature:

Multi-step reaction with 2 steps

1: trifluoroacetic acid / dichloromethane / 1 h / 20 °C

2: triethylamine / dichloromethane / 1 h / 0 - 20 °C / Inert atmosphere

With triethylamine; trifluoroacetic acid; In dichloromethane;

DOI:10.1002/anie.201100293

upstream raw materials:

tert-butyl benzyl(prop-2-yn-1-yl-3-d)carbamate

C₁₅H₂₀⁽²⁾HNO₂

(Z)-N-benzylprop-2-en-3-d-1-amine

phenyl isocyanate