ethyl 2-acetamido-5-(benzyloxycarbonylamino)-2-cyanopentanoate

Base Information

• Chemical Name: ethyl 2-acetamido-5-(benzyloxycarbonylamino)-2-cyanopentanoate
• CAS No.: 1237540-37-2
• Molecular Formula: C₁₈H₂₃N₃O₅
• Molecular Weight: 361.398
• Mol file: 1237540-37-2.mol

Synonyms:ethyl 2-acetamido-5-(benzyloxycarbonylamino)-2-cyanopentanoate

Chemical Property of ethyl 2-acetamido-5-(benzyloxycarbonylamino)-2-cyanopentanoate

Chemical Property:

Purity/Quality:

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MSDS Files:

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Technology Process of ethyl 2-acetamido-5-(benzyloxycarbonylamino)-2-cyanopentanoate

There total 1 articles about ethyl 2-acetamido-5-(benzyloxycarbonylamino)-2-cyanopentanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 41.2%

benzyl N-(3-bromopropyl)carbamate (39945-54-5) + ethyl 2-acetamido-2-cyanoacetate (90877-70-6,4977-62-2) → ethyl 2-acetamido-5-(benzyloxycarbonylamino)-2-cyanopentanoate (1237540-37-2)

Guidance literature:

ethyl 2-acetamido-2-cyanoacetate; With sodium; In ethanol; for 0.5h; Inert atmosphere; Heating;

benzyl N-(3-bromopropyl)carbamate; In ethanol; at 20 ℃; Inert atmosphere; Reflux;

DOI:10.1039/c002796k

Reference yield: 40.3%

di-tert-butyl dicarbonate (24424-99-5) + ethyl 2-acetamido-5-(benzyloxycarbonylamino)-2-cyanopentanoate (1237540-37-2) → ethyl 2-acetamido-5-(benzyloxycarbonylamino)-2-((tert-butoxycarbonylamino)-methyl)pentanoate (1237540-38-3)

Guidance literature:

di-tert-butyl dicarbonate; ethyl 2-acetamido-5-(benzyloxycarbonylamino)-2-cyanopentanoate; With sodium tetrahydroborate; nickel(II) chloride hexahydrate; In methanol; at 20 ℃; Cooling with ice; Inert atmosphere;

With 3-azapentane-1,5-diamine; In methanol; at 20 ℃; for 1h; Inert atmosphere;

DOI:10.1039/c002796k

upstream raw materials:

benzyl N-(3-bromopropyl)carbamate

ethyl 2-acetamido-2-cyanoacetate

Downstream raw materials:

ethyl 2-acetamido-5-(benzyloxycarbonylamino)-2-((tert-butoxycarbonylamino)-methyl)pentanoate