tert-butyl (S)-2-((Z)-2-{5-fluoro-2-[(1aR,7bS)-4-methoxycarbonyl-1,1a,2,7b-tetrahydrocyclopropa[c]chromen-5-ylsulfamoyl]phenyl}ethenyl)pyrrolidine-1-carboxylate

Base Information

Chemical Name:tert-butyl (S)-2-((Z)-2-{5-fluoro-2-[(1aR,7bS)-4-methoxycarbonyl-1,1a,2,7b-tetrahydrocyclopropa[c]chromen-5-ylsulfamoyl]phenyl}ethenyl)pyrrolidine-1-carboxylate
CAS No.:1609201-45-7
Molecular Formula:C₂₉H₃₃FN₂O₇S
Molecular Weight:572.655
Hs Code.:

tert-butyl (S)-2-((Z)-2-{5-fluoro-2-[(1aR,7bS)-4-methoxycarbonyl-1,1a,2,7b-tetrahydrocyclopropa[c]chromen-5-ylsulfamoyl]phenyl}ethenyl)pyrrolidine-1-carboxylate

Synonyms:tert-butyl (S)-2-((Z)-2-{5-fluoro-2-[(1aR,7bS)-4-methoxycarbonyl-1,1a,2,7b-tetrahydrocyclopropa[c]chromen-5-ylsulfamoyl]phenyl}ethenyl)pyrrolidine-1-carboxylate

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Chemical Property of tert-butyl (S)-2-((Z)-2-{5-fluoro-2-[(1aR,7bS)-4-methoxycarbonyl-1,1a,2,7b-tetrahydrocyclopropa[c]chromen-5-ylsulfamoyl]phenyl}ethenyl)pyrrolidine-1-carboxylate

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Technology Process of tert-butyl (S)-2-((Z)-2-{5-fluoro-2-[(1aR,7bS)-4-methoxycarbonyl-1,1a,2,7b-tetrahydrocyclopropa[c]chromen-5-ylsulfamoyl]phenyl}ethenyl)pyrrolidine-1-carboxylate

There total 10 articles about tert-butyl (S)-2-((Z)-2-{5-fluoro-2-[(1aR,7bS)-4-methoxycarbonyl-1,1a,2,7b-tetrahydrocyclopropa[c]chromen-5-ylsulfamoyl]phenyl}ethenyl)pyrrolidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 181760-30-5
tert-butyl (S)-2-((Z)-2-tributylstannanylethenyl)pyrrolidine-1-carboxylate

: 1609200-99-8
methyl (1aR,7bS)-5-(2-bromo-4-fluorobenzenesulfonylamino)-1,1 a,2,7b-tetrahydrocyclopropa[c]chromene-4-carboxylate

: 1609201-45-7
tert-butyl (S)-2-((Z)-2-{5-fluoro-2-[(1aR,7bS)-4-methoxycarbonyl-1,1a,2,7b-tetrahydrocyclopropa[c]chromen-5-ylsulfamoyl]phenyl}ethenyl)pyrrolidine-1-carboxylate

Guidance literature:: With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tri tert-butylphosphoniumtetrafluoroborate; In 1,4-dioxane; dimethyl sulfoxide; at 85 ℃; for 2h; Inert atmosphere; Sealed tube;

Reference yield:

: 351003-45-7
2-bromo-4-fluorobenzene-1-sulfonyl chloride

: 1609201-45-7
tert-butyl (S)-2-((Z)-2-{5-fluoro-2-[(1aR,7bS)-4-methoxycarbonyl-1,1a,2,7b-tetrahydrocyclopropa[c]chromen-5-ylsulfamoyl]phenyl}ethenyl)pyrrolidine-1-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: pyridine / dichloromethane / 2.17 h / 0 - 20 °C / Inert atmosphere

2: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tri tert-butylphosphoniumtetrafluoroborate / 1,4-dioxane; dimethyl sulfoxide / 2 h / 85 °C / Inert atmosphere; Sealed tube

With pyridine; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tri tert-butylphosphoniumtetrafluoroborate; In 1,4-dioxane; dichloromethane; dimethyl sulfoxide;

Reference yield:

: 1412976-22-7
methyl (1aR,7bS)-5-amino-1,1 a,2,7b-tetrahydrocyclopropa[c]chromene-4-carboxylate

: 1609201-45-7
tert-butyl (S)-2-((Z)-2-{5-fluoro-2-[(1aR,7bS)-4-methoxycarbonyl-1,1a,2,7b-tetrahydrocyclopropa[c]chromen-5-ylsulfamoyl]phenyl}ethenyl)pyrrolidine-1-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: pyridine / dichloromethane / 2.17 h / 0 - 20 °C / Inert atmosphere

2: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tri tert-butylphosphoniumtetrafluoroborate / 1,4-dioxane; dimethyl sulfoxide / 2 h / 85 °C / Inert atmosphere; Sealed tube

With pyridine; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tri tert-butylphosphoniumtetrafluoroborate; In 1,4-dioxane; dichloromethane; dimethyl sulfoxide;